DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KDR and Ret

DIOPT Version :10

Sequence 1:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens
Sequence 2:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster


Alignment Length:1354 Identity:321/1354 - (23%)
Similarity:523/1354 - (38%) Gaps:376/1354 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    76 VTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYI-- 138
            :.|.|:.:|.|   ||      ...::....|.:..:..|:|..: ::|.: .::...|.:|:  
  Fly    39 INEESESIFSK---IP------LAQFQVLRMEDNRLASDYLYSLE-QNPLL-RINSSSGEIYMRT 92

Human   139 ---TENKNKTVVIPC---------LGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYM 191
               :.|.:.|.::..         |.::|:|::.:..: |.:.:..:...|.:.|...:||....
  Fly    93 DYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQ-PLEEYCSELEHICFWSSAQYTIAESH 156

Human   192 ISYAGMVFCE-AKINDESYQSIMYIVVVVGYRIYDVVLSPSH--------------------GIE 235
            ..|....|.| ..|...:.::..|:...|... |.:....||                    |:.
  Fly   157 GPYRRKDFFEPVLIGALNSRAAKYLCPHVSLE-YSLNAGSSHFVLKQNRLYTRQTLDHDELNGLN 220

Human   236 LSVGE-KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTR 299
            ...|: :..:.||.                      ||.:||        .:||...|.|..:.|
  Fly   221 AKAGQLQARITCTV----------------------KLSSRD--------QRKFSRILDIKLLDR 255

Human   300 SDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAK-YLGYP----- 358
            :|.|        ..:.:.:|.|....|:|:  |.:..|:..:....::..:.|. :|.|.     
  Fly   256 NDNG--------PKLQESSSKFDFYLEQPY--FQADEEAGKKVIYVDKDTLEANAHLVYAVHNDS 310

Human   359 ----PPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYV 419
                .|:...|      |::||   |...||:....|.:.| .|....|       :.|||    
  Fly   311 HGLFRPDCHAY------EADHT---GRPHTIVSCQLRFSRN-GVFRETP-------YCVSL---- 354

Human   420 PPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEE 484
              :..:.:::|.||:      .:.|..|.     :||:.....|.|  .|..||:    |....:
  Fly   355 --EARDLTIVSRVDA------MSATANVC-----YHINLSKLHESE--QELPQAL----PLRARQ 400

Human   485 WR--SVEDFQG---GNKIEVNKNQFALIEGKNKTVSTL--------VIQAANVSALYKCEAV--- 533
            .|  ..|:|.|   |..:......:      :|.||..        |:|..:...|.:..::   
  Fly   401 HRIFESEEFNGDSAGRSLSPPTVDY------DKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFD 459

Human   534 ---NKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHV 595
               :|:|      :|.:|....|....:.|..|:...:::       |.|:||  :..|.|. ||
  Fly   460 IVEDKLG------AFGITSTSGIVFVKNPQVLEEAPETIY-------FLNVTW--IDQQRLS-HV 508

Human   596 GELPTPVC--KNLDTLWKLNATMFSNSTNDILI---------MELKNASLQDQGDYVCLAQDR-- 647
            ..:...:.  :..:|..:|.....|.:...|..         :.....|.|.:|....:...|  
  Fly   509 RVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYG 573

Human   648 --KTKKRHCVVRQLTVLERVAP-------TITGNL-------ENQTTSIGESIEVSCTASG---- 692
              ..:.|:|.......||.:.|       |..|.:       ||:......|....|..:|    
  Fly   574 SCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC 638

Human   693 -----NPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEA-- 750
                 .|..:....:.|||..|..          |.:||....::.|.......||..|..|.  
  Fly   639 APLDEEPKMKKPRKRKNETEAEPL----------LGVRRGTPPNQPLQDPMLLGVLNVAGFECDR 693

Human   751 ---FFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIIL---------------------RTVKR 791
               ||:|                  ...:.|.|||:.:|                     :.:..
  Fly   694 SCMFFVI------------------TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPE 740

Human   792 ANGGE-----LKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEA 851
            :.||:     |::|:                 |.....:||||||::|:|...||.|.||||::.
  Fly   741 SGGGDFALMPLQSGF-----------------RFESGDAKWEFPREKLQLDTVLGEGEFGQVLKG 788

Human   852 DAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV 916
            .|..|.......||||||||:|:...|:.||:||.::|..:.|. ||:.||||||....||: |:
  Fly   789 FATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-II 851

Human   917 EFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEK 981
            |:.::|:|.:|||..|.    .:..|..|..|.:     ||::|.                    
  Fly   852 EYARYGSLRSYLRLSRK----IECAGVDFADGVE-----PVNVKM-------------------- 887

Human   982 SLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICD 1046
                                   ::.:::|:.|||.:|:..|.:||||||||:||::..:.||.|
  Fly   888 -----------------------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISD 929

Human  1047 FGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKI 1111
            |||.||:|:|..|:::...|:|:||||||::.|.|||.:|||||||||.||:.:||||||||: .
  Fly   930 FGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-A 993

Human  1112 DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYI 1176
            .:.....||.|.||..|:..:..:|..:..||..||:.||:|..|......||..||:     ||
  Fly   994 PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-----YI 1053

Human  1177 VL---PISETLSMEEDSGLSLPTSPVSCMEEEEV----CDPKFHYDNTAGISQYLQNSKRKSRPV 1234
            .|   .:|..|...:||  :|.|:.:.  |.|.:    ..||..||.....:.|.|:  .:..||
  Fly  1054 DLETNAVSNPLYCGDDS--ALITTELG--EPESLQHLWSPPKIAYDIHDQATSYDQS--EEEMPV 1112

Human  1235 SVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASE-ELK-TLEDR-TKLSPSFGGM 1285
            :........|..|.:      :.|.:|.||..| :|: .|..| :..:||:..|
  Fly  1113 TSTAPPGYDLPRPLL------DATANGQVLRYENDLRFPLNIRKSSCTPSYSNM 1160

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 20/122 (16%)
Ig strand A 224..228 CDD:409448 1/3 (33%)
Ig strand A' 234..238 CDD:409448 0/3 (0%)
Ig strand B 240..249 CDD:409448 2/9 (22%)
Ig strand C 256..261 CDD:409448 0/4 (0%)
Ig strand C' 264..266 CDD:409448 0/1 (0%)
Ig strand D 270..278 CDD:409448 4/7 (57%)
Ig strand E 286..294 CDD:409448 3/7 (43%)
Ig strand F 304..310 CDD:409448 0/5 (0%)
Ig strand G 315..321 CDD:409448 1/5 (20%)
IgI_VEGFR-2 329..417 CDD:409450 20/97 (21%)
Ig strand A 329..332 CDD:409450 0/2 (0%)
Ig strand A' 339..343 CDD:409450 0/3 (0%)
Ig strand B 345..356 CDD:409450 1/11 (9%)
Ig strand C 360..366 CDD:409450 1/5 (20%)
Ig strand C' 368..371 CDD:409450 0/2 (0%)
Ig strand D 376..379 CDD:409450 1/2 (50%)
Ig strand E 381..386 CDD:409450 1/4 (25%)
Ig strand F 394..402 CDD:409450 2/7 (29%)
Ig strand G 408..417 CDD:409450 3/8 (38%)
IG_like 565..661 CDD:214653 18/110 (16%)
I-set 667..754 CDD:400151 23/114 (20%)
Ig strand B 684..688 CDD:409353 0/3 (0%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 1/3 (33%)
Ig strand F 734..739 CDD:409353 1/4 (25%)
VEGFR-2_TMD 759..793 CDD:375470 5/54 (9%)
PTKc_VEGFR2 826..1167 CDD:270681 132/340 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 4/13 (31%)
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 126/333 (38%)

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