DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KDR and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_002244.1	Gene:	KDR / 3791	HGNCID:	6307	Length:	1356	Species:	Homo sapiens
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	137/365 - (37%)
Similarity:	199/365 - (54%)	Gaps:	67/365 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   814 DEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 878
            :.:|:|       |||||.|||....||.||||||...:|..|:......|||||.|||.||..:
  Fly   457 EANCDR-------WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVD 514

Human   879 HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGA 943
            .:.|:|||:::..:..|:|||:|||.||.. .|..||:|:...|.|.|||||.|.|
  Fly   515 RKDLLSELEVMKSLEPHINVVHLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSRAE--------- 569

Human   944 RFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICY 1008
                 :.|                        |....||               :.||...|..:
  Fly   570 -----RHY------------------------GNTHGKS---------------NVLTSCDLTSF 590

Human  1009 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA 1073
            .:||||||::|.||..|||||||||||:::.:..|:.|||.|||:.....|.||.:.:||::|||
  Fly   591 MYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMA 655

Human  1074 PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQT 1138
            .|:::|.:::::||:||||:|:|||.:||::||||:.. .:..|::::|.|:..|::...|:|..
  Fly   656 TESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNI 719

Human  1139 MLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL 1178
            |..||..:|.:||.|:|:::.|..||...     .|||.|
  Fly   720 MYYCWSHDPQERPLFAEIIQMLDKLLHTE-----MDYIEL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDR	NP_002244.1	Ig	41..109	CDD:299845
		IG_like	231..324	CDD:214653
		Ig1_VEGFR	239..326	CDD:143270
		IG_like	340..417	CDD:214653
		Ig2_VEGFR-2	348..417	CDD:143272
		Ig_2	551..661	CDD:290606
		IG	565..661	CDD:214652
		I-set	667..754	CDD:254352
		IGc2	680..744	CDD:197706
		PTKc_VEGFR2	826..1167	CDD:270681	131/340 (39%)
		Pkinase_Tyr	834..1160	CDD:285015	122/325 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1318
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	122/325 (38%)
		PTKc	474..742	CDD:270623	120/322 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4350
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760