DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KDR and InR

DIOPT Version :10

Sequence 1:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens
Sequence 2:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster


Alignment Length:1693 Identity:360/1693 - (21%)
Similarity:609/1693 - (35%) Gaps:528/1693 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    23 GLPSVSLDLPRLSIQK----------------DILTIKANTTLQITCRG-----------QRDLD 60
            ||.|:|...|.||:.:                |::.:..:....||..|           .|.:|
  Fly   396 GLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTID 460

Human    61 WL--WPNNQSGSEQRVEVTECSDGLFCKTLTIPKVI----GNDTGAYKCFYRETDLASVIYVY-- 117
            ||  ...|::   |.|.:||......|:....|..|    |:||.|.     |.:|.:...::  
  Fly   461 WLEILAENET---QLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAI-----EGELNASCQLHNN 517

Human   118 --------------VQDYRSPFIASVSDQH--------GVVYITENKNKTVVIPCLG-SISNLNV 159
                          .:..|:..|    |:|        |...|.:|.|:: .|.|.. |.:|:.:
  Fly   518 RRLCWNSKLCQTKCPEKCRNNCI----DEHTCCSQDCLGGCVIDKNGNES-CISCRNVSFNNICM 577

Human   160 SLCARYPEKRFVPDGNRISWDSKKGFTIPSYMIS--YAGMVF----------------------- 199
            ..|   |:..:..|...::  :.:..|:..:..:  |:|:.:                       
  Fly   578 DSC---PKGYYQFDSRCVT--ANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEP 637

Human   200 ---------CEAKIND--ESYQSIMYIVVVVGYRIYDVVLSPSHGI----ELSVGEKLV--LNCT 247
                     |.:.:.|  |..:......::.|.....:.:....|.    ||..|...|  :..:
  Fly   638 CPGGKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSS 702

Human   248 ARTELNVGI----------DFNWEYP--SSKHQHKKLVNRDLKTQSGSEMKKF------------ 288
            ....|..|:          :.:.:.|  :.|:....|.||||....|.....|            
  Fly   703 LMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNP 767

Human   289 -LSTLTIDGV-----------TRSDQG------------------LYTCAASSGLM---TK---- 316
             |...||:.:           .:||.|                  |.:..|:|.::   ||    
  Fly   768 KLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIG 832

Human   317 -----KNSTFVRVHEKPFVAF---------GSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKN 367
                 .|:|.|....:.|:.|         |:..:| .:....:|.::.:       ||    |:
  Fly   833 EPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKS-SDDPCDDRWKVSS-------PE----KS 885

Human   368 GIPLESN---HTIKAGHVLTIMEVS------ERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQI 423
            |:.:.||   :|..:.:|.| |.:|      |.|..|:.   |||....|.:.||:..:      
  Fly   886 GVMVLSNLIPYTNYSYYVRT-MAISSELTNAESDVKNFR---TNPGRPSKVTEVVATAI------ 940

Human   424 GEKSLISPVDSY---QYG--TTQTLTCTVYAIPPPHHIHWYW------QLEEEC-ANEPSQAVS- 475
             ..|.|:...||   .||  |...:...:...|..::...|.      .:|.:. |..|::.:| 
  Fly   941 -SDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISD 1004

Human   476 -VTNPYPCEEW---RSVEDF-----QGGNKIEVNKNQFALIEG--KNKTVSTLVIQAANVSALYK 529
             :.....|.|.   .|.:::     |.|.:.|.....|..:..  |:|..|:.....|..:||..
  Fly  1005 PLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDS 1069

Human   530 CEAVNKVGRGERVISFHVTRGPEITLQPDMQPTE------------QESVSLWCTADRSTFENLT 582
                |.:..|.......  |..::.|:|::...|            .::.:.:...|.:|:::..
  Fly  1070 ----NAIPNGGATNPSR--RRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEE 1128

Human   583 WYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMF-----SNSTNDILIM-----ELKNASLQDQ 637
            ......|...:...|||.            |.|.|     .:.|...:.:     |:.:..|:|.
  Fly  1129 DLSSNKQFYEVFAKELPP------------NQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDT 1181

Human   638 -------GDYVCLAQDRKTKKRHCVVRQLTV-LERVAPTITGNLENQTTSIGESIEVSCTASGNP 694
                   .||..:.|..|.||...:|..|.| ||..         |.|.|   .:.|..|...:|
  Fly  1182 SFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHA---------NNTES---PVRVRWTPPVDP 1234

Human   695 PPQIMWF------KDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYT--CQACSVLGCAKVEAF 751
            ..:|:.:      :..:.:.|...|...|.|:  |...:.|.:||||:  .:|.|:.|..     
  Fly  1235 NGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQ--TAGYLIKLNEGLYSFRVRANSIAGYG----- 1292

Human   752 FIIEGAQEKTNLE-IIILVGTAVIAMFFWLL------LVIILRTVKRANGGELKTGYL------- 802
                   :.|.:| |.:....:...:|||||      |::.|            .||:       
  Fly  1293 -------DFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSL------------FGYVCYLHKRK 1338

Human   803 ----SIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR 863
                .:.|:.:..|.....:.:|.|   ||..|:.:....|||:|:||.|.|............|
  Fly  1339 VPSNDLHMNTEVNPFYASMQYIPDD---WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDR 1400

Human   864 TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL 928
            ..|:|.:.|.||..|....:||..::.....: :||.|||.|:: |.|.:|::|..|.|:|.:||
  Fly  1401 ECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSR-GQPALVVMELMKKGDLKSYL 1463

Human   929 RSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPE 993
            |:.|.|        .|......|:..|         .:|.:....:.|.:.:.::          
  Fly  1464 RAHRPE--------ERDEAMMTYLNRI---------GVTGNVQPPTYGRIYQMAI---------- 1501

Human   994 DLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 1058
                             ::|.||.:||::|.:||||||||.::::...|||.|||:.|||| :.|
  Fly  1502 -----------------EIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY-ETD 1548

Human  1059 YVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG 1122
            |.||| ...||::||.||::.|.||:..|||:||||:|||:.:|.|.||.|:. :|:..|.:.:|
  Fly  1549 YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDG 1612

Human  1123 TRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL-------------QANAQQDGKD 1174
            ..|..|:.....:::.|..|||...|.||:|.:::.:|....             :|..|...|:
  Fly  1613 GVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKE 1677

Human  1175 ---------YIVLPISETL---SMEEDSGLSL--------------PTSPVSCMEEEEVCDPKFH 1213
                     :..:|:.:.|   ..:||:...|              |.||::.::::....|   
  Fly  1678 RKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLP--- 1739

Human  1214 YDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVK---VIPDDNQTDS--GMVLASEELKTLE 1273
            :...:|   ::.:|....:.|....|::||..:.::.   |:||.:..|.  |..:.....|..|
  Fly  1740 FSLPSG---FIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRGYEIYDPSPKCAE 1801

Human  1274 DRTKLSPSFGG--------MVPSKSRE--------------------SVASEGSNQTSGYQSGYH 1310
            ..|..|.|.||        ::|.|.|:                    |.||.||:..|.:     
  Fly  1802 LPTSRSGSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSH----- 1861

Human  1311 SDDTDTTVYSSEEAELLKLIEIGV---------------QTGSTA-------QILQPDSGTTLSS 1353
                      :....|.|.:...|               :|||.|       ......|.|.|:|
  Fly  1862 ----------TGRPSLKKTVADSVRNKANFINRHLFNHKRTGSNASHKSNASNAPSTSSNTNLTS 1916

Human  1354 PPV 1356
            .||
  Fly  1917 HPV 1919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 30/173 (17%)
Ig strand A 224..228 CDD:409448 0/3 (0%)
Ig strand A' 234..238 CDD:409448 2/7 (29%)
Ig strand B 240..249 CDD:409448 1/10 (10%)
Ig strand C 256..261 CDD:409448 0/14 (0%)
Ig strand C' 264..266 CDD:409448 0/1 (0%)
Ig strand D 270..278 CDD:409448 4/7 (57%)
Ig strand E 286..294 CDD:409448 2/20 (10%)
Ig strand F 304..310 CDD:409448 1/5 (20%)
Ig strand G 315..321 CDD:409448 3/14 (21%)
IgI_VEGFR-2 329..417 CDD:409450 25/105 (24%)
Ig strand A 329..332 CDD:409450 1/2 (50%)
Ig strand A' 339..343 CDD:409450 0/3 (0%)
Ig strand B 345..356 CDD:409450 1/10 (10%)
Ig strand C 360..366 CDD:409450 2/5 (40%)
Ig strand C' 368..371 CDD:409450 1/2 (50%)
Ig strand D 376..379 CDD:409450 1/2 (50%)
Ig strand E 381..386 CDD:409450 2/4 (50%)
Ig strand F 394..402 CDD:409450 1/7 (14%)
Ig strand G 408..417 CDD:409450 3/8 (38%)
IG_like 565..661 CDD:214653 21/112 (19%)
I-set 667..754 CDD:400151 20/94 (21%)
Ig strand B 684..688 CDD:409353 1/3 (33%)
Ig strand C 697..701 CDD:409353 1/3 (33%)
Ig strand E 720..724 CDD:409353 0/3 (0%)
Ig strand F 734..739 CDD:409353 2/6 (33%)
VEGFR-2_TMD 759..793 CDD:375470 10/40 (25%)
PTKc_VEGFR2 826..1167 CDD:270681 110/354 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 14/71 (20%)
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032 15/68 (22%)
Furin-like 510..645 CDD:395614 18/144 (13%)
Recep_L_domain 663..781 CDD:460032 20/117 (17%)
FN3 791..>964 CDD:442628 43/195 (22%)
FN3 1224..1302 CDD:238020 20/91 (22%)
PTKc_InsR_like 1364..1652 CDD:173625 110/335 (33%)

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