DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDR and btl

DIOPT Version :9

Sequence 1:	NP_002244.1	Gene:	KDR / 3791	HGNCID:	6307	Length:	1356	Species:	Homo sapiens
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1107	Identity:	301/1107 - (27%)
Similarity:	428/1107 - (38%)	Gaps:	356/1107 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   234 IELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGS---EMKKFLSTLTID 295
            ::.:.|....|||:.......|::.:|            ::.|.:...|.   ::|::  :||:.
  Fly   152 VQRTAGGLFQLNCSPMDPDAKGVNISW------------LHNDTQILGGRGRIKLKRW--SLTVG 202

Human   296 GVTRSDQGLYTC-AASSGLMTKKNSTFVRV----HEKPF----------VAFGS--GMESLVEAT 343
            .:...|.|.|.| ........:.|.|.:.|    |..|.          :|.|.  .:|.|:|.:
  Fly   203 QLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDS 267

Human   344 VGERVRIPAKYLGYPPPEIKWYKNG-----------------IPLESNHTI---KAGHVLTIMEV 388
            ..|             |:|.|...|                 :|::....|   ....||.:..|
  Fly   268 ALE-------------PKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNV 319

Human   389 SERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPP 453
            ...|.|.|..|..|.:.:...:..|             .|.||.|:   .|.:|.|.|..|.|.|
  Fly   320 LMEDGGWYICIAENQVGRTVAASYV-------------DLYSPSDT---TTVRTTTTTTVASPIP 368

Human   454 HHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLV 518
                       ..:........|.||
  Fly   369 -----------TASTGEDNDDDVENP--------------------------------------- 383

Human   519 IQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTW 583
              ||..|.          |.|..|....:.|     ||..:   ...:|:|.|......  |:||
  Fly   384 --AAEASG----------GVGPPVFRKELKR-----LQHSL---SGNTVNLACPVYGKA--NITW 426

Human   584 YKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRK 648
            .| ..:||.   .||...|.||    |.|.   |..:|:            :|.|.|.|    :.
  Fly   427 TK-DKKPLN---RELGVYVQKN----WTLR---FVEATS------------EDSGLYNC----KV 464

Human   649 TKKRHCVVRQLTV----LERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE 709
            .....|:....:|    ..|.||.|... :|||..:..|:.:.||...:..|.:.|.:
  Fly   465 CNAWGCIQFDFSVQINDRTRSAPIIVVP-QNQTVKVNGSLVMKCTVYSDLHPTVSWKR------- 521

Human   710 DSGIVLK----DG-------NRN---------LTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 754
               :|||    ||       |.|         ||:|.|..:.||.|||.|.|.||.:....:..:
  Fly   522 ---VVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRV 583

Human   755 EGAQEKTNLEI--------------------IILVGTAVIAMFF------------------WLL 781
              ......|||                    :.|:|:|.|....                  |..
  Fly   584 --VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTK 646

Human   782 LVIILRTVKRANGGELKTG------YLSIV----------------MDPD------ELPLDEHCE 818
            .|||.|.     |||..:|      .:.::                .||.      |.|||
  Fly   647 KVIIYRP-----GGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLD---- 702

Human   819 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATC--RTVAVKMLKEGATHSEHRA 881
                  |.||.||.:|.||..||.||||:|:.|:|.|:.::...  ..|||||:||..|.::..:
  Fly   703 ------SNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMAS 761

Human   882 LMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFR 946
            |:.|::::..||.|:|::||||.|:: ||||.||||:...|||..:|:..|
  Fly   762 LVREMEVMKMIGKHINIINLLGCCSQ-GGPLWVIVEYAPHGNLKDFLKQNR-------------- 811

Human   947 QGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQ 1011
                     |...:||.|         |.|::::|.|...:.           |..:.|..::||
  Fly   812 ---------PGAPQRRSD---------SDGYLDDKPLISTQH-----------LGEKELTKFAFQ 847

Human  1012 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPE 1075
            :|:|||:||||:||||||||||:|:|:..|:||.|||||||| :|.:|.||. :.|||:||||||
  Fly   848 IARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPE 911

Human  1076 TIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML 1140
            ::.::.|..||||||:|||||||.:.|..|||.:...||....|..|.||..|...:..:|..|.
  Fly   912 SLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMR 976

Human  1141 DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL--PISET--LSMEEDSGLSL----PTS 1197
            .|||.|...||||:||||....:||..:......|:.|  |:.||  .|.:||.|...    .||
  Fly   977 QCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETS 1041

Human  1198 PV 1199
            |:
  Fly  1042 PL 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDR	NP_002244.1	Ig	41..109	CDD:299845
		IG_like	231..324	CDD:214653	17/93 (18%)
		Ig1_VEGFR	239..326	CDD:143270	18/94 (19%)
		IG_like	340..417	CDD:214653	17/96 (18%)
		Ig2_VEGFR-2	348..417	CDD:143272	15/88 (17%)
		Ig_2	551..661	CDD:290606	25/109 (23%)
		IG	565..661	CDD:214652	23/95 (24%)
		I-set	667..754	CDD:254352	30/106 (28%)
		IGc2	680..744	CDD:197706	23/83 (28%)
		PTKc_VEGFR2	826..1167	CDD:270681	146/343 (43%)
		Pkinase_Tyr	834..1160	CDD:285015	140/328 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1318
btl	NP_001014583.1	IG_like	149..232	CDD:214653	17/93 (18%)
		IGc2	157..215	CDD:197706	14/71 (20%)
		IG	247..336	CDD:214652	20/101 (20%)
		Ig	258..340	CDD:143165	18/94 (19%)
		I-set	394..479	CDD:254352	28/121 (23%)
		IGc2	408..469	CDD:197706	22/89 (25%)
		IG_like	492..583	CDD:214653	28/101 (28%)
		Ig	507..583	CDD:299845	24/85 (28%)
		PKc_like	700..1000	CDD:304357	148/354 (42%)
		TyrKc	712..996	CDD:197581	140/328 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810