Protein Alignment KDR and Tie

DIOPT Version :10

• Sequence 1: NP_002244.1
• Gene: KDR / 3791
• HGNCID: 6307
• Length: 1356
• Species: Homo sapiens
• Sequence 2: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Alignment Length: 1105
• Identity: 243/1105 - (21%)
• Similarity: 388/1105 - (35%)
• Gaps: 399/1105 - (36%)

Human   304 LYTCAASSGLMT---KKNSTFVRVHE--KPFVAFGSG-------MESLVEATVGERVRIPAKYLG 356
            |::..:|.||..   ::|.|...:.:  ||.| .|.|       ||..||....|..  |..|.|
  Fly   286 LFSDESSHGLFVVAKEQNGTLNHIADGTKPAV-MGKGIPSKTNSMEDDVEEEEDELK--PYVYFG 347

Human   357 YPPPEIKWYKNGIPLESNHTIKAG-----HVLTIMEVSERDTGNYTVILTN----PISKEKQSHV 412
            ...|.|:  ..|:      ||||.     |. .::|||...:...|:..|:    |:|..:
  Fly   348 AKLPPIR--PGGL------TIKAAEGDDDHP-RVLEVSVAQSTTPTITTTSTTPAPVSSTR---- 399

Human   413 VSLVVYVPPQIGEKSLISPVD----SYQY-----GTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 468
                    |....:..::||:    .|:|     |...|      |.|||             |.
  Fly   400 --------PTASTRRPLTPVERSRSKYKYHMRERGLVPT------AAPPP-------------AA 437

Human   469 EPSQAVSVTNPYPCEEWRSVEDFQGGNK-----------IEVNKNQFALIEGKNKTVSTLVIQAA 522
            .|:..||.|.            :.|..:           ::..:::.|      |.|...|:|..
  Fly   438 PPAPPVSRTR------------YVGSGRPTAGLSDSIQDLKQTESEVA------KPVVRRVVQKV 484

Human   523 NVSA-------LYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFEN 580
            :.|:       :...|....||:.|.:.:...|.....|...:...|...:.:...|...||.:.
  Fly   485 SPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKR 549

Human   581 LTWYKLGPQPLPIHVGELPTPVCK----NLDTLWKLNATMFSNSTNDILIME------------- 628
            .|      ...|:.....||....    :..|....:.|:...:|....|:|
  Fly   550 TT------TNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPAL 608

Human   629 LKNASLQDQGDYVCLAQD---------RKTKKRHCV-----VRQLTVLERVAPTITGNLENQTTS 679
            .:..::.|..:.:....:         .:|:..|..     :.:.|||..:..|:    ..:.||
  Fly   609 TREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTV----HPRPTS 669

Human   680 IGESIEVSCTASGNPPPQIMWFKDNET---LVEDSG----------IVLKDGNRNLTIRRVRKED 731
            ...:...:.||    ||.:. ...||.   :||.|.          ::..:.:.|:.:||:
  Fly   670 TSTTTSTTTTA----PPAVT-APSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRM---- 725

Human   732 EGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVI---AMFFWLLLVIILRTVKRAN 793
                                          ||..::||...||   |:..:|:...::|  :||.
  Fly   726 ------------------------------NLVTLVLVAVGVIPLAAIILYLVRNFVIR--RRAK 758

Human   794 GGE--------------LKTGYLSIVMDPDELPLD-------------------EHCERLPYD-- 823
            ..|              :|.......:|.||..:|                   :|.:.:|..
  Fly   759 QSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQA 823

Human   824 -------------------ASKW-EFPRDRLKLGKPLGRGAFGQVIEADA------FGIDKTATC 862
                               ||:: :|.|..::|...||.|.||||.:|:|      ||    ||
  Fly   824 SQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG----AT- 883

Human   863 RTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTY 927
            |.||||.::   ..|...:|..|..|:..:|.|.|||.|||||.: ..|.|:|:|:...|.|.:.
  Fly   884 RIVAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVE-SEPHMLIMEYAMRGRLLSL 944

Human   928 LRSKRN--EFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
            ||:.|:  ..:|....|.|                                     ||
  Fly   945 LRAARSATNILPASVPGGR-------------------------------------SL------- 965

Human   991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK 1055
            ||       |:...|..::..:|.|||::|.|:.:||||||||:||....:.||||||::.|:
  Fly   966 AP-------LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-- 1021

Human  1056 DPDYVRK--------------------------------------------------GDAR---- 1066
            |.:.:||                                                  |:.:
  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086

Human  1067 ---------LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG 1122
                     ||::|||||::...::|.::|:|:||::||||.:||::||..: ...|..||:.:|
  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQG 1150

Human  1123 TRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQD--GKDYI-VLPISETL 1184
            .|...|..:..|.|..|..|||.||..||:|::....:...|......|  ..||: |...||.|
  Fly  1151 LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDL 1215

Human  1185  1184
              Fly  1216  1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDR	NP_002244.1	IgI_VEGFR	224..326	CDD:409448	6/24 (25%)
		Ig strand A	224..228	CDD:409448
		Ig strand A'	234..238	CDD:409448
		Ig strand B	240..249	CDD:409448
		Ig strand C	256..261	CDD:409448
		Ig strand C'	264..266	CDD:409448
		Ig strand D	270..278	CDD:409448
		Ig strand E	286..294	CDD:409448
		Ig strand F	304..310	CDD:409448	1/5 (20%)
		Ig strand G	315..321	CDD:409448	1/8 (13%)
		IgI_VEGFR-2	329..417	CDD:409450	26/103 (25%)
		Ig strand A	329..332	CDD:409450	1/2 (50%)
		Ig strand A'	339..343	CDD:409450	2/3 (67%)
		Ig strand B	345..356	CDD:409450	3/10 (30%)
		Ig strand C	360..366	CDD:409450	2/5 (40%)
		Ig strand C'	368..371	CDD:409450	1/2 (50%)
		Ig strand D	376..379	CDD:409450	2/2 (100%)
		Ig strand E	381..386	CDD:409450	1/4 (25%)
		Ig strand F	394..402	CDD:409450	1/7 (14%)
		Ig strand G	408..417	CDD:409450	0/8 (0%)
		IG_like	565..661	CDD:214653	15/126 (12%)
		I-set	667..754	CDD:400151	15/99 (15%)
		Ig strand B	684..688	CDD:409353	0/3 (0%)
		Ig strand C	697..701	CDD:409353	0/3 (0%)
		Ig strand E	720..724	CDD:409353	1/3 (33%)
		Ig strand F	734..739	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	759..793	CDD:375470	10/36 (28%)
		PTKc_VEGFR2	826..1167	CDD:270681	118/412 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1274..1318
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/391 (29%)