DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KDR and tor

DIOPT Version :9

Sequence 1:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens
Sequence 2:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster


Alignment Length:954 Identity:239/954 - (25%)
Similarity:370/954 - (38%) Gaps:312/954 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   460 WQLEEECANEPSQAVSV--------TNPYPCEEW----RSVEDFQGGNKIEVNKNQFALIEG--K 510
            :|:...|..|......:        |.|.|...:    .:|:|......:.::.:.|.::.|  .
  Fly    77 YQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLES 141

Human   511 NKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADR 575
            |.|        .|::||        ...|:...|.........||....||::..:|:|      
  Fly   142 NST--------HNITAL--------AMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNL------ 184

Human   576 STFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNA------TMFSNSTNDILIMELKNASL 634
                    .:..|||..:|      .:...::  ||.:|      .|.|.|||.:.:.|    .|
  Fly   185 --------LRFVPQPDDLH------HIAAEIE--WKPSAESNCYFDMVSYSTNSVNMDE----PL 229

Human   635 QDQGDYVCLAQDRKTKKRHCV------------VRQLTVLERVAPTITGNLENQTTSIGESIE-- 685
            :.|      .:|||...||.|            ||.:.::.|    :..:|:....::...::  
  Fly   230 EVQ------FRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNR----LESDLQWLPIAVPSCLDWY 284

Human   686 ----VSCTASGNPP--------------PQIM-----WFK-----DNETL-VEDSGIVLKDGNR- 720
                ..|     ||              |.|:     |.:     ||.|| :.|   :.|.|.. 
  Fly   285 PYNYTLC-----PPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFD---LFKGGTEL 341

Human   721 NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGA---------QEKTNLEIIILVGTAVIAM 776
            |.|:.:.|..    :.....:||| :..|...:.:.|         .:|.:..:::..|..|..:
  Fly   342 NYTLDQNRSH----FYVPKITVLG-SHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLV 401

Human   777 FFWL-----LLVIILRTVKRANGGELKT------------GYLSIVMDP---------------- 808
            .|.:     :|::...|..|.|..|::.            .:||: ||.                
  Fly   402 LFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSL-MDSSGLLVTLSANESLEVM 465

Human   809 DELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEG 873
            |||.::.|                .:.|...||.||||.|..    |:.|.   |.||||:||:.
  Fly   466 DELEVEPH----------------SVLLQDVLGEGAFGLVRR----GVYKK---RQVAVKLLKDE 507

Human   874 ATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPY 938
            ....:..|...|:::|..:|.|.|:|.::|..|:....:|:::|:|..|:|..:||.:       
  Fly   508 PNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREE------- 565

Human   939 KTKGARFRQGKDYVGAIP-----VDLKR-----------RLDSITSSQSSASSGFVEEKS----- 982
                .:|||.::.:|...     ||.:|           |::.|.:|..|.    |||:|     
  Fly   566 ----WKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLST----VEEESESDQT 622

Human   983 -----------------------LSDVEE---------EEAPEDLYK-------------DF--- 999
                                   |.|:|.         .|||:|..|             ||   
  Fly   623 HSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSD 687

Human  1000 -------------------------LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEK 1039
                                     |....|:..:.|||.||||||..|.:||||||||:|:|..
  Fly   688 NKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVD 752

Human  1040 NVVKICDFGLARDIYKDPDYVRK--GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLG 1102
            ..:||.||||:||:|.:..| ||  |..:||:||:|.|::..:|||.|||||||||||:||.:||
  Fly   753 RSIKIADFGLSRDVYHENVY-RKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLG 816

Human  1103 ASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQAN 1167
            ..|||.|. ..:..:.|::|.||:.|:..|.||:..|..||...||.|||||.|...||.::.|.
  Fly   817 GMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILAT 880

Human  1168 AQQDGKDYI-VLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDP 1210
              .|..:.: .|..:....::...||:.....|.| |||...:|
  Fly   881 --NDVPERLKQLQAATESKLKSCDGLNSKVEQVPC-EEELYLEP 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDRNP_002244.1 Ig 41..109 CDD:299845
IG_like 231..324 CDD:214653
Ig1_VEGFR 239..326 CDD:143270
IG_like 340..417 CDD:214653
Ig2_VEGFR-2 348..417 CDD:143272
Ig_2 551..661 CDD:290606 29/127 (23%)
IG 565..661 CDD:214652 25/113 (22%)
I-set 667..754 CDD:254352 21/118 (18%)
IGc2 680..744 CDD:197706 17/95 (18%)
PTKc_VEGFR2 826..1167 CDD:270681 142/436 (33%)
Pkinase_Tyr 834..1160 CDD:285015 140/421 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
torNP_476762.1 FN3 199..261 CDD:214495 19/73 (26%)
STYKc 475..873 CDD:214568 140/421 (33%)
PTKc 479..873 CDD:270623 139/417 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.