DRSC/TRiP Functional Genomics Resources

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Protein Alignment KDR and Ror

DIOPT Version :10

Sequence 1:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens
Sequence 2:NP_476962.1 Gene:Ror / 34367 FlyBaseID:FBgn0010407 Length:685 Species:Drosophila melanogaster


Alignment Length:695 Identity:166/695 - (23%)
Similarity:265/695 - (38%) Gaps:240/695 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   601 PVCKNLDTLWKLNATMFSN-STNDILIMELKNASLQDQGDYVCLAQDRKT----KKRHCV----- 655
            |:|:   |..:.|...|:| :||   ..:|||.|::.:.   ..::|.|.    ||:..:     
  Fly   104 PICR---TPERTNLLYFANVATN---AKQLKNVSIRRKR---TKSKDIKNISIFKKKSTIYEDVF 159

Human   656 ----------VRQLTVLERVAPTITGNLENQ-------------------------------TTS 679
                      .|:...|:|:.......|||:                               ..|
  Fly   160 STDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGMVGVEDCQKLPQHKDCLS 224

Human   680 IGESIEVSCT------------------ASGNPPPQIMW---------------FKDNETLVEDS 711
            :|.:|||..|                  |||.|..:..|               :..|...||:|
  Fly   225 LGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENS 289

Human   712 GIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAM 776
            .....|.:|...|             :.|.:..||              ..:.|.|:..||.|.:
  Fly   290 PWCFVDSSRERII-------------ELCDIPKCA--------------DKIWIAIVGTTAAIIL 327

Human   777 FFWLLLVIIL---RTVK--------------------------------RANGGELK--TGYLSI 804
            .|.::..|||   ||:.                                |.|.|.|.  ....|.
  Fly   328 IFIIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSK 392

Human   805 VMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKM 869
            :::.:.|....|            |....::..:.||.||||:|.:......:||..  |||:|.
  Fly   393 LIERNTLLRINH------------FTLQDVEFLEELGEGAFGKVYKGQLLQPNKTTI--TVAIKA 443

Human   870 LKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNE 934
            |||.|:....:....|::::..:.|. |:|.:||..... .|..::.|:...|:|..:|      
  Fly   444 LKENASVKTQQDFKREIELISDLKHQ-NIVCILGVVLNK-EPYCMLFEYMANGDLHEFL------ 500

Human   935 FVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDF 999
                                           |::|.:       |.||||.:|           |
  Fly   501 -------------------------------ISNSPT-------EGKSLSQLE-----------F 516

Human  1000 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGD 1064
            |.:      :.|:::||::|::...:||||||||.|::|..||||.||||:||||....|..:..
  Fly   517 LQI------ALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSK 575

Human  1065 ARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPD 1129
            :.||::||..|:|....:|.:||||||||:||||:|.|..||.|.. ::|....::....:.||:
  Fly   576 SLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFS-NQEVINLIRSRQLLSAPE 639

Human  1130 YTTPEMYQTMLDCWHGEPSQRPTFSELVE-----HLGNLLQANAQ 1169
            .....:|..|::|||.:..:||||:::..     |.|:...:|.:
  Fly   640 NCPTAVYSLMIECWHEQSVKRPTFTDISNRLKTWHEGHFKASNPE 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448
Ig strand A 224..228 CDD:409448
Ig strand A' 234..238 CDD:409448
Ig strand B 240..249 CDD:409448
Ig strand C 256..261 CDD:409448
Ig strand C' 264..266 CDD:409448
Ig strand D 270..278 CDD:409448
Ig strand E 286..294 CDD:409448
Ig strand F 304..310 CDD:409448
Ig strand G 315..321 CDD:409448
IgI_VEGFR-2 329..417 CDD:409450
Ig strand A 329..332 CDD:409450
Ig strand A' 339..343 CDD:409450
Ig strand B 345..356 CDD:409450
Ig strand C 360..366 CDD:409450
Ig strand C' 368..371 CDD:409450
Ig strand D 376..379 CDD:409450
Ig strand E 381..386 CDD:409450
Ig strand F 394..402 CDD:409450
Ig strand G 408..417 CDD:409450
IG_like 565..661 CDD:214653 17/79 (22%)
I-set 667..754 CDD:400151 24/150 (16%)
Ig strand B 684..688 CDD:409353 3/3 (100%)
Ig strand C 697..701 CDD:409353 1/18 (6%)
Ig strand E 720..724 CDD:409353 1/3 (33%)
Ig strand F 734..739 CDD:409353 0/4 (0%)
VEGFR-2_TMD 759..793 CDD:375470 12/68 (18%)
PTKc_VEGFR2 826..1167 CDD:270681 104/345 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
RorNP_476962.1 CRD_TK_ROR_like 39..228 CDD:143568 24/132 (18%)
KR 235..312 CDD:214527 15/103 (15%)
PTKc_Ror 404..673 CDD:270642 103/346 (30%)
Blue background indicates that the domain is not in the aligned region.

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