DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KDR and ver-4

DIOPT Version :10

Sequence 1:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens
Sequence 2:NP_509835.2 Gene:ver-4 / 186632 WormBaseID:WBGene00006897 Length:1216 Species:Caenorhabditis elegans


Alignment Length:1414 Identity:306/1414 - (21%)
Similarity:517/1414 - (36%) Gaps:441/1414 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    24 LPSVSLDLPRLSIQKDILTIK--------------ANTTLQITCRGQ-RDLDWLWPNNQS----- 68
            |..|...|..::|:.|...:|              .|..:.:||.|| ::|....|..:.     
 Worm    11 LAQVVTTLQPITIKVDFHEVKHHESIGDYVELVEGKNRDISLTCYGQHKNLKIEPPKREEHAGFP 75

Human    69 --GSEQRVE------------VTECSDGLFCKTLTIPKVIGNDTGAYKCF---YRETDLASVIYV 116
              |.....|            |.:|                 |||:|.|.   ::|:.|.:.:::
 Worm    76 EIGIRTSAEWKKNEYWFLLKNVRQC-----------------DTGSYYCVSDEFKESMLQNTVHI 123

Human   117 YVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGS--ISNLNVSLCARYPEKRFVPDGNRISW 179
            :|:.. ..|:...:..|      |:....::|||..:  :...||.|.....:......|    :
 Worm   124 FVRKL-DIFVPLKTIYH------EHNGSEIIIPCKTTKFVDTKNVELYVNQVKLNSALQG----Y 177

Human   180 DSKKGFTIPS--YMISYAGMVFCEAKINDESYQSIMYIV--------VVVGYRIY-----DVVLS 229
            |.:.||.:..  |.:.....||.|.|..::|.|.:.|.:        ::..|..|     ||   
 Worm   178 DQRYGFKLTKNMYTMKPNSTVFFECKYTNDSNQDLDYYISNSDPDATLIDQYFFYWEKSNDV--- 239

Human   230 PSHGIELSV----------------GEKLVLNCTAR--------------TELNVGIDFNWEYPS 264
            |..|...|:                .:::||.|...              .:.:.|:.|.  .||
 Worm   240 PYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSAHEIEKRSSGLRFG--DPS 302

Human   265 SKH--------QHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTC-------------- 307
            |:.        ::.:|...|.||.         .|:....:|..|.|:|.|              
 Worm   303 SQDIVEKNTMLRYDRLSVYDRKTS---------RTVNFQNLTSEDSGIYRCTWRNRSKTNIVLDY 358

Human   308 ---------------AASSGLMTKKNST---FVR-----VHEKPFVA-----FGSGME------- 337
                           .:...|..:||.:   ||:     :::|.:.|     :.|.:|       
 Worm   359 DLNFNQKGTQIKIIETSKQRLKMRKNESTLLFVKFAVFPINKKNYTAKWSRLYNSTVEGGQQVET 423

Human   338 -------SLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDT 393
                   .:...|.|..|.:....|..|..|:    :||.:  .||..| ...|..|:|| |.|.
 Worm   424 IRNGFFRQITTKTSGRNVFLETLNLKSPKIEM----SGIYVLSISNMDI-VQQVKWIIEV-ENDE 482

Human   394 GNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHW 458
            .|..:.:.:|::..     :|..:::|                ..|..::.|...:..|...|..
 Worm   483 PNAQLTIRDPLTLN-----ISNQLFLP----------------LNTNLSIFCLAVSSSPTDVIFE 526

Human   459 YWQLEEECANEPSQAVSVTNPYPCEEW---------RSVED-FQGG---NKIEVNKNQFALIEGK 510
            | :.:|                  .||         |.::| |:.|   |.:...:..|..|..|
 Worm   527 Y-RTDE------------------NEWFRGFYKNKLRKIDDTFEKGFIYNFVLAKRTDFKCINVK 572

Human   511 NKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFH-VTRGPEIT-LQPDMQPTEQESVSLWCTA 573
            .|..||..|...:        ..||        :|| :.:....| .:|.....|.::|.|.|..
 Worm   573 KKKTSTKFITVTS--------NANK--------TFHEIEKSVNATKTEPSDIIFEGDNVRLTCVV 621

Human   574 DRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKL-NATMFSNSTNDIL----------IM 627
            .....|                          .|..||. |..|...:|...:          |:
 Worm   622 PYGAVE--------------------------FDVFWKFENPKMLKYTTFPAMHPVKDRYKRVIL 660

Human   628 ELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTV-LERVAPTITGNLENQTTSI-----GESIEV 686
            .::|.::...|.|.|:.::::.:.|.    :.:: :|:|:|...  |.|.:.||     |:..::
 Worm   661 NVRNITIDFTGTYYCIVKNKEFEHRF----ETSISVEKVSPPFL--LNNNSRSIISASNGQMFDI 719

Human   687 SCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAF 751
            :|..:|.|.|...||||.....:...|    ||. |.:.:..|.|.|::.|.|.:..|       
 Worm   720 NCKVNGVPTPDYTWFKDGYPYTKGKVI----GNA-LHVSKAEKRDNGIFWCSATNRAG------- 772

Human   752 FIIEGAQEKTNLEII-ILVGTAVIAMFFWLLLVIILRTV--------------KRANGGELKTGY 801
                     |.::.| :.|..|..:.||||.:......|              |.....||....
 Worm   773 ---------TTIDYIEVKVAGASSSSFFWLFITFFAFVVVGIVVSLLWKLFGQKDLKPSELSLNN 828

Human   802 LSIVMDP----------DELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFG-------QVI 849
            |....|.          :.||::|..:.|.|: ..:|...:.|::.:.||.|.||       .:.
 Worm   829 LKRATDEYQKYTVSEKINNLPVEERIDYLTYN-EDYEIDLENLEILETLGSGQFGIVKKGYLNMA 892

Human   850 EADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPL 912
            .:..||.:...   :||:|...:.:.....:....|||::..|..|.||::|:||.||  ..|.|
 Worm   893 SSKNFGFESRL---SVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGEL 954

Human   913 MVIVEFCKFGNLSTYLRSKR----NEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSA 973
            .::.|....|||..:||.:|    ||.|         .:|..::..:..::.:|           
 Worm   955 FIVTELIDGGNLREFLRERRDVFANELV---------EKGYIFLTNVRENVPKR----------- 999

Human   974 SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 1038
                       :||:|:...|.:....|.: |:....|:|.||::||:..|:|||||.||:|:|:
 Worm  1000 -----------EVEKEQLLIDEFNSLCTSD-LLSIGLQIANGMDWLANIPCVHRDLACRNVLISK 1052

Human  1039 KNVVKICDFGLARDIYKDPDY--VRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFS 1100
            ..:::|.|||||:. :.|..|  ||:. |..||::||..|:|.|..:|.:|||||:|:.|:|||:
 Worm  1053 TKIIRIADFGLAKK-HTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFT 1116

Human  1101 LGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165
            ||.:|||... :......:|.|...:.|.....::|:.|..||...|..||||:|.::...|.:|
 Worm  1117 LGGTPYPDCP-NFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLFKNHIQ 1180

Human  1166 ANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHY 1214
            ..|.:     ::..|.:.|..|:::                  ..||||
 Worm  1181 YFASK-----LLQQIEKDLECEKNN------------------QQKFHY 1206

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 29/181 (16%)
Ig strand A 224..228 CDD:409448 3/8 (38%)
Ig strand A' 234..238 CDD:409448 0/3 (0%)
Ig strand B 240..249 CDD:409448 3/8 (38%)
Ig strand C 256..261 CDD:409448 1/4 (25%)
Ig strand C' 264..266 CDD:409448 1/1 (100%)
Ig strand D 270..278 CDD:409448 2/7 (29%)
Ig strand E 286..294 CDD:409448 1/7 (14%)
Ig strand F 304..310 CDD:409448 2/34 (6%)
Ig strand G 315..321 CDD:409448 2/8 (25%)
IgI_VEGFR-2 329..417 CDD:409450 23/108 (21%)
Ig strand A 329..332 CDD:409450 1/7 (14%)
Ig strand A' 339..343 CDD:409450 0/3 (0%)
Ig strand B 345..356 CDD:409450 2/10 (20%)
Ig strand C 360..366 CDD:409450 1/5 (20%)
Ig strand C' 368..371 CDD:409450 2/2 (100%)
Ig strand D 376..379 CDD:409450 1/2 (50%)
Ig strand E 381..386 CDD:409450 1/4 (25%)
Ig strand F 394..402 CDD:409450 1/7 (14%)
Ig strand G 408..417 CDD:409450 1/8 (13%)
IG_like 565..661 CDD:214653 16/106 (15%)
I-set 667..754 CDD:400151 24/91 (26%)
Ig strand B 684..688 CDD:409353 0/3 (0%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 1/3 (33%)
Ig strand F 734..739 CDD:409353 1/4 (25%)
VEGFR-2_TMD 759..793 CDD:375470 10/48 (21%)
PTKc_VEGFR2 826..1167 CDD:270681 109/356 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
ver-4NP_509835.2 IG_like 611..692 CDD:214653 17/110 (15%)
Ig strand B 615..619 CDD:409353 2/3 (67%)
Ig strand C 629..633 CDD:409353 1/3 (33%)
Ig strand E 658..662 CDD:409353 1/3 (33%)
Ig strand F 672..677 CDD:409353 2/4 (50%)
Ig 709..782 CDD:472250 21/93 (23%)
Ig strand B 717..721 CDD:409582 0/3 (0%)
Ig strand C 730..734 CDD:409582 0/3 (0%)
Ig strand F 762..767 CDD:409582 1/4 (25%)
Ig strand G 775..778 CDD:409582 0/2 (0%)
STYKc 870..1175 CDD:214568 106/341 (31%)
Blue background indicates that the domain is not in the aligned region.

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