DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KDR and ver-3

DIOPT Version :10

Sequence 1:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens
Sequence 2:NP_509836.1 Gene:ver-3 / 181289 WormBaseID:WBGene00006896 Length:1227 Species:Caenorhabditis elegans


Alignment Length:1381 Identity:318/1381 - (23%)
Similarity:526/1381 - (38%) Gaps:348/1381 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     7 LAVALWLCVETRAASVGLPSVSLDLPRL----SIQKDILTIKANTTLQITCRGQR--DLDWLWPN 65
            |.:.:.|.:...:||...|::.::..::    ||.| .:.::.:|.|.:.|....  ||.:.:|:
 Worm     3 LKLTVLLILVHASASYKPPAIEVEDYQVQEHDSIGK-FVELEEHTRLILKCSAHHNGDLKYNFPS 66

Human    66 -------NQSGSEQRVEVTECSDGLF-CKTLTIPKVIGNDTGAYKCFYRE-TDLASVIYVYVQDY 121
                   :::..::|:|  |..|..| .|.||:..|..:|||.|.|...| :.|...|||:|. .
 Worm    67 MEGNVGYDENNFKKRME--EYYDDAFGDKVLTLNDVRESDTGTYSCSSMEHSSLNDTIYVFVH-R 128

Human   122 RSPFIASVSDQHGVVYITENKNKTVVIPCLGS--ISNLNVSLCARYPEKRFVPDGNRISWDSKKG 184
            :..|:...|..  ::|    |...|::||..:  :...::.|   |.....|.:.::.::|.:.|
 Worm   129 KKVFLPLKSVM--IIY----KQGEVMVPCKTTKFVDKSDIEL---YASNVLVKEASKYNYDQRYG 184

Human   185 FTIPSYMISYAGMVFC--EAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELS---------V 238
            |.|...:.|...:|..  |.:...|..|:..||:.       :...|...|...|         |
 Worm   185 FKITKKLYSEKQIVDVNFECRYKKEENQTATYIIT-------EKEASSDDGYHFSWEKGFQWPHV 242

Human   239 GEKLVLNCTAR-----------TELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTL 292
            |....|.|...           .:|::      |.|...|.....|:.|.....|:   |..:|:
 Worm   243 GYNFSLTCNLNYNGSKIFHGYTNKLSI------ECPQCSHDPGSHVHVDRHRIIGN---KISTTV 298

Human   293 TIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEAT-------VGERVRI 350
            .|..:...|.|.|||....   ..|.:.:...|  .:||.......::|.:       ......:
 Worm   299 RIQHLELEDSGKYTCIWEH---ENKETKYTDYH--LYVAPKKAQIKVIETSPTIMRIKENRATSL 358

Human   351 PAKYLGYPPPE----IKW---YKNGI-------------------------PLESNHTIKAGHVL 383
            .||:..||..:    .||   |.:.|                         ....|..|||..|.
 Worm   359 TAKFAIYPFEKESYTAKWSRIYNSSIHEGPQSETIINDDFRKIAATSFGDGAFSENLDIKAFAVS 423

Human   384 T------IMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQT 442
            |      ::.:|..||   ..::...::.|.....|.:.|..|...    .||..:.|:..|...
 Worm   424 TNMSGTYVLSISHMDT---VQVVQWEVAIENDEPDVQITVREPSSF----FISNQEYYKPDTNLH 481

Human   443 LTCTVYAIPPPHHIHWYWQLEEECAN--EPSQAVSVTNPY----------------PCEEWRSVE 489
            :.|...:|||...:..|.....|...  ||::.|||...:                .|...|   
 Worm   482 IECISISIPPADVVFEYKTKNSEQFQEIEPNKLVSVGGTFDRGLIYNVTFTEGMDLKCSSIR--- 543

Human   490 DFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEIT 554
              :|...|.|||    ||                           |:|.|..|...|........
 Worm   544 --KGNRAITVNK----LI---------------------------KIGEGFEVRPHHEKSSKATE 575

Human   555 LQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSN 619
            .:|.....|.::|.|.|.                  .|:...:            |.::....::
 Worm   576 SEPSKIIYEGDNVKLTCV------------------FPLDSDD------------WSVSWRFENS 610

Human   620 STNDI-----------------LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAP 667
            .::||                 ||:.|::.:....|.|.|:.::..::|  .:...:.|.....|
 Worm   611 KSSDISSIPTTTETEIKQYSKHLILNLRDVTTSFTGTYTCVVKNEDSEK--LLETSIDVKAISKP 673

Human   668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNE--TLVEDSGIVLKDGNRNLTIRRVR 728
            :|||...|....:  .:..|::|..:|.|||...||||..  |..:..|.:|:       :.|.|
 Worm   674 SITGGNSNAVVIVDYDQYFEINCNMTGTPPPVYQWFKDGNPYTHGDVDGSILR-------VSRAR 731

Human   729 KEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN-LEIIILVGTAVIAMFFWLLLVIILRTV--- 789
            .||:|.:.|.|.:..|              :|.| :|:.:.........|:|.|.:::|.::   
 Worm   732 GEDDGEFHCLATNRAG--------------DKLNSIEVQVNNAPKGSLFFYWFLALLLLISIIAV 782

Human   790 ------KRANGG-------ELKTGYLSIVMD-----PDE---LPLDEHCERLPYDASKWEFPRDR 833
                  .||:..       .|.|.|.:::..     |:|   ||::|....|||: :.:|.....
 Worm   783 FLLTCKLRASNRLTKQKDIALNTLYETMIKHQAGPLPEEMKDLPVEERTYYLPYN-NDYEIDPVN 846

Human   834 LKLGKPLGRGAFGQVIEADAFGID------KTATCRTVAVKMLKEGATHSEHRALMSELKILIHI 892
            |::..|:|.|.|| |::....|:.      ::.|...||||...........:.:..|||::..|
 Worm   847 LEILNPIGSGHFG-VVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAI 910

Human   893 GHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAI 955
            ..:.||:.|:||.||  ..|.|.::.||...|||..:|::.||.|:....:.........|:  :
 Worm   911 PKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINELVEDEHVPVDDSYL--V 973

Human   956 PVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA 1020
            |..:|:::..........:...||:                .|.|....|:....|:||||.:||
 Worm   974 PNSVKKKIYKFDEKLGEGTRLLVED----------------PDALCTSDLLSIGLQIAKGMAWLA 1022

Human  1021 SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVR---KGDARLPLKWMAPETIFDRVY 1082
            ...|:|||||.||:|:::..:|:|.||||::. :.:..|.|   ..|..||::||..|.|.:..:
 Worm  1023 DVPCVHRDLACRNVLITKTKIVRIADFGLSKK-HTNKTYYRTKKSKDTPLPVRWMPLECIEEFKF 1086

Human  1083 TIQSDVWSFGVLLWEIFSLGASPYPGVKIDE--EFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHG 1145
            |.:|||||||:.|:|||:||.:|||......  ||   ::.|.|.:.|:|...|:|:.|..||..
 Worm  1087 TQKSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEF---IRNGNRNKQPEYCHDEIYELMKVCWQF 1148

Human  1146 EPSQRPTF---------------SELVEHLGNLLQANAQQDGK--DYIVLPISETLSMEEDS--- 1190
            .|..||||               |:.:|.:.|:|....|:..|  |:|           :||   
 Worm  1149 NPKDRPTFNDCITFFENHMRDSSSQFLERVENMLHTEMQEQSKLDDWI-----------QDSRPD 1202

Human  1191 --GLSLPTSPVSCMEE 1204
              .:|...||....||
 Worm  1203 VPNVSFQKSPKKQKEE 1218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 23/121 (19%)
Ig strand A 224..228 CDD:409448 0/3 (0%)
Ig strand A' 234..238 CDD:409448 1/12 (8%)
Ig strand B 240..249 CDD:409448 2/8 (25%)
Ig strand C 256..261 CDD:409448 0/4 (0%)
Ig strand C' 264..266 CDD:409448 0/1 (0%)
Ig strand D 270..278 CDD:409448 2/7 (29%)
Ig strand E 286..294 CDD:409448 2/7 (29%)
Ig strand F 304..310 CDD:409448 3/5 (60%)
Ig strand G 315..321 CDD:409448 1/5 (20%)
IgI_VEGFR-2 329..417 CDD:409450 22/132 (17%)
Ig strand A 329..332 CDD:409450 1/2 (50%)
Ig strand A' 339..343 CDD:409450 1/3 (33%)
Ig strand B 345..356 CDD:409450 2/10 (20%)
Ig strand C 360..366 CDD:409450 2/12 (17%)
Ig strand C' 368..371 CDD:409450 1/27 (4%)
Ig strand D 376..379 CDD:409450 1/2 (50%)
Ig strand E 381..386 CDD:409450 2/10 (20%)
Ig strand F 394..402 CDD:409450 0/7 (0%)
Ig strand G 408..417 CDD:409450 1/8 (13%)
IG_like 565..661 CDD:214653 14/112 (13%)
I-set 667..754 CDD:400151 26/90 (29%)
Ig strand B 684..688 CDD:409353 1/3 (33%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 0/3 (0%)
Ig strand F 734..739 CDD:409353 1/4 (25%)
VEGFR-2_TMD 759..793 CDD:375470 8/43 (19%)
PTKc_VEGFR2 826..1167 CDD:270681 112/368 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
ver-3NP_509836.1 IG_like 242..>313 CDD:214653 17/79 (22%)
IG_like 578..667 CDD:214653 16/120 (13%)
Ig strand B 588..592 CDD:409353 2/3 (67%)
Ig strand C 602..606 CDD:409353 0/3 (0%)
Ig strand E 633..637 CDD:409353 2/3 (67%)
Ig strand F 647..652 CDD:409353 2/4 (50%)
Ig_3 672..744 CDD:464046 25/78 (32%)
PTKc 851..1164 CDD:270623 106/335 (32%)
Blue background indicates that the domain is not in the aligned region.

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