Protein Alignment CG13579 and KISS1R

DIOPT Version :10

• Sequence 1: NP_001261169.1
• Gene: CG13579 / 37905
• FlyBaseID: FBgn0035010
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 104/464 - (22%)
• Similarity: 158/464 - (34%)
• Gaps: 122/464 - (26%)

  Fly    46 VLTLGVIGANCLVIFVINNRRYAAYIHQQPR----YLLTSLALNDLTIGLLITPFGLMPALFHCW 106
            ::.||::| |.|||:||..       |:..|    :.:.:||..|:|..|...||..:......|
Human    52 LMLLGLVG-NSLVIYVICR-------HKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGW 108

  Fly   107 PYGEIFCQIQALLRGALSQQSAVILVCMAVDRYMCALHPRRYYQHSSKKGCVAILSLTWIISLTV 171
            ..|:..|:....::....|.:...|..|:|||:...:.|.|.....:.:..:|:....|:.|..|
Human   109 VLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAV 173

  Fly   172 FG-FLVL------PKGYYFNNTGLMACEPFYSKP---SYRILSTCALYFPTTMVLMYCYGSSF-H 225
            .. .|.|      |:.|        ..|.|.|:.   ::.:.:..|||....:....||.:.. |
Human   174 SAPVLALHRLSPGPRAY--------CSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRH 230

  Fly   226 MSRFRLNDPTMPLTAAAHHPHPHPHPTAAQQLQMHQHQQHHQQAGMHSHLYHGHS--------HH 282
            :.|            .|..|.|     |...||:........:.|.......|.:        ..
Human   231 LGR------------VAVRPAP-----ADSALQVRGVGGRTARLGGRGGTVVGGAGGGICAGRDS 278

  Fly   283 PSHPSHPNHPNHHGHPHHHGPPVMG-HLSMAMSMGLAGM--PNMTNKITKKIVPIQEKNSSGSTS 344
            |..|               |..|.| .||.|.:..|...  |.....:.::...::.|     .|
Human   279 PRGP---------------GGAVRGDELSRAPAFRLTTFTAPPQGQVLAERAGAVRAK-----VS 323

  Fly   345 RSMAAISLGFIVMVTPWTIQEIVTACTGSKLPPFLDFLV---------------------TWT-- 386
            |.:||:.|.|             .||.|    |...|||                     ||.
Human   324 RLVAAVVLLF-------------AACWG----PIQLFLVLQALGPAGSWHPRSYAAYALKTWAHC 371

  Fly   387 -ALSNSLWNPFMYWLLNSDFRRMSRQLMPNKCFPHEDTPEHKSGCCHINANDFEITTLPIPPEPP 450
             :.|||..||.:|..|.|.||:..|::.|  |.|.......:.|.....|...|:..|...|.|.
Human   372 MSYSNSALNPLLYAFLGSHFRQAFRRVCP--CAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPA 434

  Fly   451 SSRPPGGAG 459
            .::.||.:|
Human   435 RAQKPGSSG 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13579	NP_001261169.1	7tm_classA_rhodopsin-like	41..>220	CDD:410626	43/187 (23%)
		TM helix 1	41..65	CDD:410626	9/18 (50%)
		TM helix 2	75..101	CDD:410626	8/29 (28%)
		TM helix 3	113..143	CDD:410626	7/29 (24%)
		TM helix 4	156..175	CDD:410626	4/19 (21%)
		TM helix 5	200..220	CDD:410626	3/19 (16%)
		7tm_GPCRs	<334..407	CDD:475119	25/96 (26%)
		TM helix 6	340..366	CDD:410628	6/25 (24%)
		TM helix 7	377..402	CDD:410628	12/48 (25%)
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	91/412 (22%)
		TM helix 1	45..69	CDD:410628	9/17 (53%)
		TM helix 2	78..100	CDD:410628	7/21 (33%)
		TM helix 3	116..138	CDD:410628	3/21 (14%)
		TM helix 4	161..177	CDD:410628	4/15 (27%)
		TM helix 5	202..225	CDD:410628	4/22 (18%)
		TM helix 6	323..345	CDD:410628	11/38 (29%)
		TM helix 7	363..388	CDD:410628	8/24 (33%)