DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13579 and GPR84

DIOPT Version :9

Sequence 1:	NP_001261169.1	Gene:	CG13579 / 37905	FlyBaseID:	FBgn0035010	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_065103.1	Gene:	GPR84 / 53831	HGNCID:	4535	Length:	396	Species:	Homo sapiens

Alignment Length:	440	Identity:	101/440 - (22%)
Similarity:	157/440 - (35%)	Gaps:	116/440 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NSSCSHPRYSGHNFIA-HIGIAETIEAVLILVLTLGVIGANCLVIFVINNRRYAAYIHQQPR--- 76
            |.||.|....|:.::| ..|:...:...:..||||       |.:.:            ||:
Human     8 NFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTL-------LALAI------------QPKLRT 53

  Fly    77 ---YLLTSLALNDLTIGLLITPFGLMPALFHCWPYGEIFCQIQALLRGALSQQSAVILVCMAVDR 138
               .|:.:|.|.||....|:.||.:...|...|..|..||::..||..|.:..|.:.|..:|:.|
Human    54 RFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGR 118

  Fly   139 YMCALHPRRYYQHSSKKGCVAILSLTWIISLTVFG-----FLVLPKGYYFNNTGLMACEPFYSKP 198
            |:...||:.:.|..|.||.|..|..||::.:..|.     ::::|
Human   119 YLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVP-------------------- 163

  Fly   199 SYRILSTCALYF------PTTMVLMYCYGSSFHMSRFRLNDPTMPLTAAAHHPHPHPHPTAAQQL 257
               ::.||:  |      |.|.:||..|        |.|...::.:.....|   .....|||.|
Human   164 ---VVCTCS--FDRIRGRPYTTILMGIY--------FVLGLSSVGIFYCLIH---RQVKRAAQAL 212

  Fly   258 QMHQHQQHHQQAGMHS-HLYHGHSHHPSHPSHPNHPNHHGHPHH--HGPPVMGHLSMAMSMGLAG 319
            .    |...:||.:|| |:.......|......:.....|.|..  ...||    |.|.:..|.|
Human   213 D----QYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPV----SAATTQTLEG 269

  Fly   320 -------------MPNMTNK----ITKKIVPIQ-------EKNSSGSTSRSMAAISLGFIVMVTP 360
                         ...|..|    .:.|..||:       ..:..|..:|...|:.|.|.:...|
Human   270 DSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIP 334

  Fly   361 WTIQEIVTACTGSKLPPFLDFL---VTWTALSNSLWNPFMYWLLNSDFRR 407
            :.:..|:.|..  :.|..:..|   :||.   |...||.:|..:|..||:
Human   335 FLLLNILDARV--QAPRVVHMLAANLTWL---NGCINPVLYAAMNRQFRQ 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13579	NP_001261169.1	7tm_4	51..>148	CDD:304433	26/102 (25%)
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	96/427 (22%)
		TM helix 1	22..48	CDD:320338	7/44 (16%)
		TM helix 2	55..78	CDD:320338	8/22 (36%)
		TM helix 3	93..123	CDD:320338	9/29 (31%)
		TM helix 4	137..155	CDD:320338	5/17 (29%)
		TM helix 5	175..200	CDD:320338	7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..311		13/70 (19%)
		TM helix 6	312..342	CDD:320338	7/29 (24%)
		TM helix 7	349..374	CDD:320338	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100