DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13579 and 5-HT2B

DIOPT Version :10

Sequence 1:NP_001261169.1 Gene:CG13579 / 37905 FlyBaseID:FBgn0035010 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:853 Identity:171/853 - (20%)
Similarity:269/853 - (31%) Gaps:272/853 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 SGHNFIAHIG---------IAETIE----------AVLILVLTLGVIGANCLVIFVIN-NRRYAA 69
            |.||.: |:.         |:.|.|          |:|.|||.||....|.||...|. .||   
  Fly    43 SRHNQL-HVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERR--- 103

  Fly    70 YIHQQPRYLLTSLALNDLTIGLLITPFGLMPALFHCWPYGEIFCQIQALLRGALSQQSAVILVCM 134
             :.....|.|.|||:.||.:.:|:.|.|::..:...:|.|...|.....|.......|.:.|..:
  Fly   104 -LQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTI 167

  Fly   135 AVDRYMCALHPRRYYQHSSKKGCVAILSLTWIISLTVFGFLVLPKGYYFNNTGLM---ACEPFYS 196
            :||||:...:|.|:.::.:::.....:...|::|:.:  .|.|...|..|:..::   .|:  ..
  Fly   168 SVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM--SLPLSLMYSKNHASVLVNGTCQ--IP 228

  Fly   197 KPSYRIL-STCALYFPT-TMVLMYCYGSSFHMSRFRLNDPTMPLTAAAH---------------- 243
            .|.|::: |....|.|. .|:|.||..... ::|.|.|......||||.                
  Fly   229 DPVYKLVGSIVCFYIPLGVMLLTYCLTVRL-LARQRQNLGGGQQTAAATPGWASGWLGQAPALER 292

  Fly   244 --------HPHP-------HPH--------------------------PTAAQQLQMHQH----- 262
                    .|.|       |.|                          ||......:||.     
  Fly   293 RCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEML 357

  Fly   263 ----------------QQHHQQAGMHSHLY-------------HGHSHHPSHPSHPNHPNH-HGH 297
                            .....:..:.:||.             |..|||.:|..||....| ...
  Fly   358 KLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQAS 422

  Fly   298 PH-HHGPPVMG-------------HLSMAMS-MGLAGMPNMTNKITKKI------------VPIQ 335
            |. .||..|:|             ..|:|.| ||........:::::::            ||.:
  Fly   423 PKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGR 487

  Fly   336 EKNSSGSTSRSMAAISLGFIVMVTPWTIQEIVTACTG--------SKLPPFLDFLVTWTALSNSL 392
            ||.:....:                   .|.|...|.        :.||            .|:|
  Fly   488 EKRAGHEDA-------------------DEDVETPTSTLRRHKRHNSLP------------KNAL 521

  Fly   393 W--NPFMYWLLNSD-------FRRMSRQLMPNKCFPHEDT---PEHKSGCCHI----NANDF--- 438
            :  :..:...|:.|       .::..:|.....|  |.||   |..|:..|||    :.:|:   
  Fly   522 YPRHTTVQESLDDDDDEEEESAQQKDQQTKSKIC--HSDTELDPPQKAKQCHIAGQNHQSDYLQL 584

  Fly   439 -EITTLPIPPEPPSSRPPGGAGGGGGGPSSGGPSSGGGVASSIGGSVLGICGRSRTNSLSRSASQ 502
             .:.|.|...:.|.......|.......:....::...|:||.....|.:|......||:.|.|.
  Fly   585 PSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSA 649

  Fly   503 YIRG--------TMGGGVHNHQATETFSTTRPDIEGLSEKYWGEILERTVSSGNLNAMQKHLPPH 559
            .|.|        |:|..:..|.|....|:.....:|               ||.|.|      |.
  Fly   650 GITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDG---------------SGYLAA------PG 693

  Fly   560 LPYAHHLVHQIHQ-------PQQHHQQQTTSFSKASDLQLNLNLSQAATAAELGKFSNSEPKLCE 617
            .|........|.:       ....|:::.:||   ..::.:|.|:...||..    |||...|..
  Fly   694 TPCPGRRKLSISKTASVVTWDSSRHRRRGSSF---GGVRTSLLLTPTKTATT----SNSSTPLRR 751

  Fly   618 HLFHDVNCAKSKAANGDGESSGKLACGRSIPDIXYAEDVILAKNQLLARQAKCSHHPLHQQAKTR 682
            ..  .:...::....|.||..||.....|.|.:            |..:|...|||..:....:|
  Fly   752 SA--TLRSHQNMNYQGAGECGGKTRTTTSSPCM------------LQRQQTVRSHHSRNSSVISR 802

  Fly   683 LHSHTGSL 690
            ..|..|.:
  Fly   803 NSSRHGRI 810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13579NP_001261169.1 7tm_classA_rhodopsin-like 41..>220 CDD:410626 50/184 (27%)
TM helix 1 41..65 CDD:410626 11/24 (46%)
TM helix 2 75..101 CDD:410626 10/25 (40%)
TM helix 3 113..143 CDD:410626 8/29 (28%)
TM helix 4 156..175 CDD:410626 2/18 (11%)
TM helix 5 200..220 CDD:410626 7/21 (33%)
7tm_GPCRs <334..407 CDD:475119 11/89 (12%)
TM helix 6 340..366 CDD:410628 0/25 (0%)
TM helix 7 377..402 CDD:410628 2/26 (8%)
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 54/201 (27%)
TM helix 1 75..101 CDD:320433 11/25 (44%)
TM helix 2 108..134 CDD:320433 10/25 (40%)
TM helix 3 146..176 CDD:320433 8/29 (28%)
TM helix 4 188..211 CDD:320433 4/24 (17%)
TM helix 5 229..258 CDD:320433 9/28 (32%)
7tm_GPCRs <799..893 CDD:475119 3/12 (25%)
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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