Protein Alignment CG13579 and CrzR

DIOPT Version :10

• Sequence 1: NP_001261169.1
• Gene: CG13579 / 37905
• FlyBaseID: FBgn0035010
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 730
• Identity: 133/730 - (18%)
• Similarity: 221/730 - (30%)
• Gaps: 297/730 - (40%)

  Fly     9 LVAPAVKNSSCSHPRYSGHNF-----------------IAHIGIAET-IEAVLILVLTLGVIGAN 55
            |.|.|:.|||......|.|..                 ::..|:.:. :.||:.|...||    |
  Fly    76 LPAYAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSLLG----N 136

  Fly    56 CLVIFVI--------NNRRYAAYIHQQPRYLLTSLALNDLTIGLLITPFGLMPALFHC----WPY 108
            .|.|:.|        |:|...:.|:.    |:..|::.|    :|:|.|.::.....|    |..
  Fly   137 LLTIWNIYKTRISRRNSRHTWSAIYS----LMFHLSIAD----VLVTWFCIIGEAAWCYTVQWLA 193

  Fly   109 GEIFCQIQALLRGALSQQSAVILVCMAVDRYMCALHPRRYYQHSSKKGCVAILSLTWIISLTVFG 173
            .|:.|::..|.:......|..:||.:.|||::...:|.:  ..:..|.|..:|..|:|:||.
  Fly   194 NELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLV--- 253

  Fly   174 FLVLPKGYYFNNTGLMACEPFYSKPSY---------RILSTCALYFPTTMVLMYCYGSSFHMSRF 229
             |.||:.:.|:.......|.||...::         ::.:|..|.|  |.:|..|.....:||.|
  Fly   254 -LSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLVF--TFLLPLCILFGTYMSTF 315

  Fly   230 RLNDPTMPLTAAAHHPHPHPHPTAAQQLQMHQHQQHHQQAGMHSHLYHGHSHHPSHPSHPNHPNH 294
            |                     |.:...:|.|.
  Fly   316 R---------------------TISSSEKMFQG-------------------------------- 327

  Fly   295 HGHPHHHGPPVMGHLSMAMSMGLAGMPNMTNKITKKIVPIQEKNSSGSTSRSMAAISLGFIVMVT 359
                           |...:...|.:|..||:  ::::    ..:...:.|....|.:.|::..|
  Fly   328 ---------------SKLANYSTAKLPTQTNR--QRLI----HKAKMKSLRISVVIIIAFLICWT 371

  Fly   360 PWTIQEIVTACTG--SKLPPFLDFLVTWTALSNSLWNPFMYWLLNSDFRRMSRQLMPNKCFPHED 422
            |:.:..|:.....  .:|...|...:.:..:||||.||.:|
  Fly   372 PYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY------------------------ 412

  Fly   423 TPEHKSGCCHINANDFEITTLPIPPEPPSSRPPGGAGGGGGGPSSGGPSSGGGVASSIGGSVLGI 487
                  |..|:                              .|..||.|||||
  Fly   413 ------GAFHL------------------------------CPGKGGKSSGGG------------ 429

  Fly   488 CGRSRTNSLSRSASQYIRGTMGGGVHNHQATETFSTTRPDIEGLSEKYWGEILERTVSSGNLNAM 552
             |.:...||:|..|              |.|.:..|....::|              :.|:
  Fly   430 -GNNNAYSLNRGDS--------------QRTPSMLTAVTQVDG--------------TGGS---- 461

  Fly   553 QKHLPPHLPYAHHLVHQIHQPQQHHQQQTTSFSKASDLQLNLNLSQAATAA----ELGKFSNSEP 613
                                     .:|..:|.:.|..:.:.|.:....||    ::|
  Fly   462 -------------------------SRQMRAFRQQSYYRSSSNGTAGPGAAPFKEQVG------- 494

  Fly   614 KLCEHLFHDVNCAKSKAANGDGESSGKLACGRSIPDIXYAEDVILAKNQLLARQAKCSHHPLHQQ 678
                 |.|        ...|:|...|.::.|.:       ..:|...:.|||||..|.....|||
  Fly   495 -----LLH--------VGPGNGTPGGSVSSGAT-------PQLIRKGSALLARQPSCLREQEHQQ 539

  Fly   679 AKTRLHSHTGSLRFS 693
             :..||....:|..|
  Fly   540 -RLLLHEKPSTLVLS 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13579	NP_001261169.1	7tm_classA_rhodopsin-like	41..>220	CDD:410626	49/199 (25%)
		TM helix 1	41..65	CDD:410626	10/31 (32%)
		TM helix 2	75..101	CDD:410626	6/25 (24%)
		TM helix 3	113..143	CDD:410626	8/29 (28%)
		TM helix 4	156..175	CDD:410626	6/18 (33%)
		TM helix 5	200..220	CDD:410626	5/28 (18%)
		7tm_GPCRs	<334..407	CDD:475119	15/74 (20%)
		TM helix 6	340..366	CDD:410628	5/25 (20%)
		TM helix 7	377..402	CDD:410628	8/24 (33%)
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	79/453 (17%)
		TM helix 1	120..146	CDD:320506	9/29 (31%)
		TM helix 2	160..187	CDD:320506	7/34 (21%)
		TM helix 3	198..228	CDD:320506	8/29 (28%)
		TM helix 4	239..260	CDD:320506	9/24 (38%)
		TM helix 5	288..317	CDD:320506	10/51 (20%)
		TM helix 6	350..380	CDD:320506	6/29 (21%)
		TM helix 7	391..416	CDD:320506	9/54 (17%)