DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13579 and npr-27

DIOPT Version :9

Sequence 1:	NP_001261169.1	Gene:	CG13579 / 37905	FlyBaseID:	FBgn0035010	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_501164.2	Gene:	npr-27 / 185662	WormBaseID:	WBGene00018344	Length:	366	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	77/414 - (18%)
Similarity:	137/414 - (33%)	Gaps:	109/414 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VLILVLTLGVIGANCLVIFVI------NNRRYAAYIHQQPRYLLTSLALNDLTIGLLITPFGLMP 100
            |.|:|..:|..| |..:|:.:      :.......:.|:.|..:.:||.:|:.  ||:|    :|
Worm    38 VYIVVCLVGTPG-NLWIIYKLFRAKLWSGASVQLTVSQRSRIYIFALACSDMF--LLLT----LP 95

  Fly   101 AL----FH-CWPYGEIFCQIQALLRGALSQQSAVILVCMAVDRYMCALHPRRYYQHSSKKGCVAI 160
            |.    :| .|.:|...|.|...:.......|.|:|..|:::||:......|:...       |.
Worm    96 ATASYNYHGTWIFGSAACYIIRSIEIFAKLFSVVLLTVMSLERYIIVCTRLRHIYR-------AW 153

  Fly   161 LSLTWIISLTVFGFLVLPKGYY---------FNNTGLMACEPFYSKPSYRILS--TCALYFPTTM 214
            :||..:...|:||.||....:|         |:......|.|..|...:.:.:  |..:.|....
Worm   154 MSLVPLAVGTIFGVLVPTIIHYFYLQHFSVPFDPDVTWVCLPLMSNEVFNLFAQYTFVVGFIIPF 218

  Fly   215 VLM-YCYGSSFHMSRFRLNDPTMPLTAAAHHPHPHPHPTAAQQLQMHQHQQHHQQAGMHSHLYHG 278
            .:| .||.......|.:........|.....|...|           ::....:::.....::|
Worm   219 AIMTACYIMLVRHVRTKYKMRRAQTTTTLAKPGKEP-----------RYMSEVKKSIWRIAVFH- 271

  Fly   279 HSHHPSHPSHPNHPNHHGHPHHHGPPVMGHLSMAMSMGLAGMPNMTNKITKKIVPIQEKNSSGST 343
                                         .:..|...|...:||...:|.:.:....|:.|.|.:
Worm   272 -----------------------------FVCWAPFWGFTMLPNYIYQIDQFLHGDNEEESGGES 307

  Fly   344 SRSMAAISLGFIVMVTPWTIQEIVTACTGSKLPPFLDFLVTWTALSNSLWNPFMYWLLNSDFRR- 407
            .         |:|..      .:|:.|.     |:::....|.          :|.|||.|.|:
Worm   308 I---------FLVYC------RLVSNCL-----PYINAAGNWV----------LYALLNVDVRKH 342

  Fly   408 MSRQLMPNKCFPHEDTPEHKSGCC 431
            :..|....:.|..:..|.:.|..|
Worm   343 IYNQPKKKRKFTLKFNPVNTSSNC 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13579	NP_001261169.1	7tm_4	51..>148	CDD:304433	24/107 (22%)
npr-27	NP_501164.2	7tm_classA_rhodopsin-like	35..336	CDD:381740	68/382 (18%)
		TM helix 1	35..59	CDD:381740	7/21 (33%)
		TM helix 2	77..98	CDD:381740	9/26 (35%)
		TM helix 3	114..136	CDD:381740	5/21 (24%)
		TM helix 4	162..177	CDD:381740	6/14 (43%)
		TM helix 5	203..226	CDD:381740	4/22 (18%)
		TM helix 6	258..283	CDD:381740	3/54 (6%)
		TM helix 7	296..336	CDD:381740	11/69 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100