DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3494 and CYR1

DIOPT Version :9

Sequence 1:	NP_611915.1	Gene:	CG3494 / 37903	FlyBaseID:	FBgn0035008	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	258	Identity:	64/258 - (24%)
Similarity:	96/258 - (37%)	Gaps:	66/258 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DKYHMRNTRILQVSKAQISEVPMEVFEAAQQELVNIVSLDGNRLLEMPKDLPLL----------- 83
            |...|.:.|.|.:...:||.:     :.....|.|:...| ||:......||.|
Yeast   972 DLSEMTDLRTLNLRYNRISSI-----KTNASNLQNLFLTD-NRISNFEDTLPKLRALEIQENPIT 1030

  Fly    84 --------SEHLTQLVLNKNQISFVPTN-ISQYSKLTNLSLSNNLLCDLPMELGGLRLLRNLDIS 139
                    .:::|.|.|||.|:|.:|.. :::.|.|..|.|:.|.|..||.|:..|..|..|.::
Yeast  1031 SISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVA 1095

  Fly   140 HNRFRQLPRCIYELERLETLSAHDNQIR-AIDASESGLGGMRELKRLNL-----GNNDIQ----- 193
            .|:...:|..:.:|:.|.||..|.|.|| .:|..|:     .||..||:     ||:.::
Yeast  1096 RNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMEN-----LELTSLNISSNAFGNSSLENSFYH 1155

  Fly   194 ------------------------IVPPILGKMQNLVELELWGNPFRQPRHQILSMGTPALLS 232
                                    .:.|:.....||..|.|..|.|....|..|...|...||
Yeast  1156 NMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLS 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3494	NP_611915.1	LRR	<34..>231	CDD:227223	61/251 (24%)
		leucine-rich repeat	38..62	CDD:275380	4/23 (17%)
		leucine-rich repeat	63..86	CDD:275380	7/41 (17%)
		LRR_4	85..124	CDD:289563	14/39 (36%)
		leucine-rich repeat	87..109	CDD:275380	8/22 (36%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		leucine-rich repeat	134..155	CDD:275380	4/20 (20%)
		leucine-rich repeat	156..181	CDD:275380	9/25 (36%)
		leucine-rich repeat	182..204	CDD:275380	6/55 (11%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	64/258 (25%)
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380
		leucine-rich repeat	840..864	CDD:275380
		leucine-rich repeat	865..887	CDD:275380
		leucine-rich repeat	888..910	CDD:275380
		leucine-rich repeat	911..933	CDD:275380
		leucine-rich repeat	934..956	CDD:275380
		leucine-rich repeat	957..978	CDD:275380	2/5 (40%)
		leucine-rich repeat	979..1018	CDD:275380	10/44 (23%)
		leucine-rich repeat	1019..1041	CDD:275380	1/21 (5%)
		leucine-rich repeat	1042..1065	CDD:275380	8/22 (36%)
		leucine-rich repeat	1066..1088	CDD:275380	9/21 (43%)
		leucine-rich repeat	1089..1111	CDD:275380	5/21 (24%)
		leucine-rich repeat	1167..1187	CDD:275380	1/19 (5%)
		leucine-rich repeat	1191..1211	CDD:275380	7/19 (37%)
		leucine-rich repeat	1236..1258	CDD:275380
		leucine-rich repeat	1259..1287	CDD:275380
		PP2C	1374..1617	CDD:395385
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930