DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3492 and PPIB

DIOPT Version :9

Sequence 1:	NP_611914.1	Gene:	CG3492 / 37902	FlyBaseID:	FBgn0035007	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_000933.1	Gene:	PPIB / 5479	HGNCID:	9255	Length:	216	Species:	Homo sapiens

Alignment Length:	178	Identity:	42/178 - (23%)
Similarity:	79/178 - (44%)	Gaps:	37/178 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 QIYLDIEVREARIQGRLIIQLFTEACPQVVLEFMRICT------QNNSSAIVFNRALAPIWMEGR 305
            ::|.|:.:.:..: ||:|..||.:..|:.|..|:.:.|      ..||.   |:|.:....::|.
Human    45 KVYFDLRIGDEDV-GRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSK---FHRVIKDFMIQGG 105

  Fly   306 LAMDPQR--STELTNI------EHDFEVLNHGVDAGILSFPSRYVRGNARTAVN---FTISFKPL 359
               |..|  .|...:|      :.:|::.::|        |......||....|   |.|:....
Human   106 ---DFTRGDGTGGKSIYGERFPDENFKLKHYG--------PGWVSMANAGKDTNGSQFFITTVKT 159

  Fly   360 SILNGRRIAFGKVRKGMQLLERIQ---VAVGHLPMSHNLISLTDCGVI 404
            :.|:|:.:.||||.:||:::.:::   ......|:...:|:  |||.|
Human   160 AWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIA--DCGKI 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3492	NP_611914.1	cyclophilin	249..388	CDD:294131	36/158 (23%)
PPIB	NP_000933.1	cyclophilin_ABH_like	45..203	CDD:238907	39/174 (22%)
PPIB	NP_000933.1	Prevents secretion from ER	213..216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11071
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000