DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3492 and Ranbp2

DIOPT Version :9

Sequence 1:	NP_611914.1	Gene:	CG3492 / 37902	FlyBaseID:	FBgn0035007	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_038954525.1	Gene:	Ranbp2 / 294429	RGDID:	1560047	Length:	3114	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	71/388 - (18%)
Similarity:	136/388 - (35%)	Gaps:	95/388 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DGQVEDSRPKHTFNVKRQELENNYRHHQRLIPVPTSRRTMPKIRSHIVMNEQRELYRQHRDRMSN 116
            ||..||...:..       :.|...|.:.::.:|.......:....::..|:.:|||..|| :|.
  Rat  2783 DGDDEDGSDEDV-------VHNEDIHFEPIVSLPEVEVKSGEEDEEVLFKERAKLYRWDRD-VSQ 2839

  Fly   117 IKGKVNTYLPPPKVQIEGNGMELSYMEMLTALYKKSNNTLRTFTKSPE--RLAAGRWRNANLARE 179
            .|.:             |.|       .:..|:....|..|...:..:  ::.|    |..:.:.
  Rat  2840 WKER-------------GIG-------DIKILWHSVKNYYRILMRRDQVFKVCA----NHVITKA 2880

  Fly   180 KERRQL--EKNKEFHKGGELFDPEAGKSK---RYKPKSSGSFSCEIPMHVLHRYENLMDQCDVGV 239
            .|.:.|  ..|.......:..|.||...:   |:|.|           .:...::..:::|...:
  Rat  2881 MELKPLNFSNNALVWTASDYADGEAKIEQLAVRFKTK-----------EITECFKKKIEECQQNI 2934

  Fly   240 -------------LCKLLRPQIYLDIEVREARIQGRLIIQLFTEACPQVVLEFMRICTQNNSSAI 291
                         |.|...|.::.|:.| :....||:|::||:...||....|..:||.......
  Rat  2935 MKLQNGQVSLAAELSKETNPVVFFDVCV-DGEPLGRIIMELFSNIVPQTAENFRALCTGEKGFGF 2998

  Fly   292 ---VFNRALAPIWMEGRLAMDPQRSTELTNI--------------EHDFEVLNHGVDAGILSFPS 339
               :|:|.:.....:|         .::|..              :.:|::.:.|  .|:||..:
  Rat  2999 KNSIFHRVVPDFICQG---------GDITKYNGTGGQSIYGDKFDDENFDLKHTG--PGLLSMAN 3052

  Fly   340 RYVRGNARTAVNFTISFKPLSILNGRRIAFGKVRKGMQLLERIQVAVGHLPMSHNLISLTDCG 402
               .|....:..|.|:.|....|:.:.:.||.|:.||..:.:|:............|.:|:||
  Rat  3053 ---CGQNTNSSQFFITLKKAEHLDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSRRICITECG 3112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3492	NP_611914.1	cyclophilin	249..388	CDD:294131	32/155 (21%)
Ranbp2	XP_038954525.1	TPR	<18..126	CDD:223533
		TPR repeat	59..89	CDD:276809
		RanBD1_RanBP2-like	1180..1296	CDD:270203
		zf-RanBP	1345..1374	CDD:395516
		RanBP2-type Zn finger	1350..1369	CDD:275375
		zf-RanBP	1410..1438	CDD:395516
		RanBP2-type Zn finger	1414..1433	CDD:275375
		zf-RanBP	1473..1502	CDD:395516
		RanBP2-type Zn finger	1477..1496	CDD:275375
		zf-RanBP	1533..1563	CDD:395516
		RanBP2-type Zn finger	1537..1556	CDD:275375
		zf-RanBP	1596..1625	CDD:395516
		RanBP2-type Zn finger	1600..1619	CDD:275375
		zf-RanBP	1655..1683	CDD:395516
		RanBP2-type Zn finger	1659..1678	CDD:275375
		RanBD2_RanBP2-like	1902..2018	CDD:269998
		RanBD3_RanBP2-like	2199..2315	CDD:270204
		IR1-M	2529..2590	CDD:403422
		IR1-M	2605..2663	CDD:403422
		RanBD4_RanBP2-like	2815..2931	CDD:269999	24/151 (16%)
		cyclophilin_ABH_like	2954..3112	CDD:238907	35/172 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810