DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3492 and Ranbp2

DIOPT Version :9

Sequence 1:	NP_611914.1	Gene:	CG3492 / 37902	FlyBaseID:	FBgn0035007	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_035370.2	Gene:	Ranbp2 / 19386	MGIID:	894323	Length:	3053	Species:	Mus musculus

Alignment Length:	398	Identity:	72/398 - (18%)
Similarity:	139/398 - (34%)	Gaps:	94/398 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VYNTHNPNLVGLDGQVEDSRPKHTFNVKRQELENNYRHHQRLIPVPTSRRTMPKIRSHIVMNEQR 104
            |:.|...:..|.|....|....|..::          |.:.::.:|.......:....::..|:.
Mouse  2713 VFGTQTTSKGGEDEDGSDEDVVHNEDI----------HFEPIVSLPEVEVKSGEEDEEVLFKERA 2767

  Fly   105 ELYRQHRDRMSNIKGKVNTYLPPPKVQIEGNGMELSYMEML--TALYKKSNNTLRTFTKSPERLA 167
            :|||..|| :|..|.:     ....::|..:.|:..|..::  ..::|...|  ...||
Mouse  2768 KLYRWDRD-VSQWKER-----GIGDIKILWHTMKKYYRILMRRDQVFKVCAN--HVITK------ 2818

  Fly   168 AGRWRNANLAREKERRQLEKNKEFHKGGELFDPEAGKSK---RYKPKSSGSFSCEIPMHVLHRYE 229
                     |.|.:...:..|.......:..|.||...:   |:|.|           .:...::
Mouse  2819 ---------AMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTK-----------EMTESFK 2863

  Fly   230 NLMDQCDVGV-------------LCKLLRPQIYLDIEVREARIQGRLIIQLFTEACPQVVLEFMR 281
            ...::|...:             |.|...|.::.|: ..:....||:|::||:...||....|..
Mouse  2864 KKFEECQQNIIKLQNGHTSLAAELSKDTNPVVFFDV-CADGEPLGRIIMELFSNIVPQTAENFRA 2927

  Fly   282 ICTQNNSSAI---VFNRALAPIWMEGRLAMDPQRSTELTNI--------------EHDFEVLNHG 329
            :||.......   :|:|.:.....:|         .::|..              :.:|::.:.|
Mouse  2928 LCTGEKGFGFKNSIFHRVVPDFICQG---------GDITKYNGTGGQSIYGDKFDDENFDLKHTG 2983

  Fly   330 VDAGILSFPSRYVRGNARTAVNFTISFKPLSILNGRRIAFGKVRKGMQLLERIQVAVGHLPMSHN 394
              .|:||. :.|  |....:..|.|:.|....|:.:.:.||.|:.||..:.:|:...........
Mouse  2984 --PGLLSM-ANY--GQNTNSSQFFITLKKAEHLDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSR 3043

  Fly   395 LISLTDCG 402
            .|.:|:||
Mouse  3044 RICITECG 3051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3492	NP_611914.1	cyclophilin	249..388	CDD:294131	32/155 (21%)
Ranbp2	NP_035370.2	TPR 1	26..59
		TPR_11	59..126	CDD:290150
		TPR repeat	59..89	CDD:276809
		TPR 2	60..93
		TPR_1	60..92	CDD:278916
		TPR 3	94..128
		TPR 4	165..201
		TPR 5	288..319
		TPR 6	583..616
		TPR 7	648..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..802
		RCR	<839..925	CDD:304939
		20 X 2 AA repeats of F-G. /evidence=ECO:0000305	1000..3035		68/380 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1171
		RanBD1_RanBP2-like	1180..1296	CDD:270203
		zf-RanBP	1345..1374	CDD:279035
		RanBP2-type Zn finger	1350..1369	CDD:275375
		zf-RanBP	1410..1438	CDD:279035
		RanBP2-type Zn finger	1414..1433	CDD:275375
		zf-RanBP	1469..1498	CDD:279035
		RanBP2-type Zn finger	1473..1492	CDD:275375
		zf-RanBP	1499..1524	CDD:279035
		RanBP2-type Zn finger	1502..1521	CDD:275375
		zf-RanBP	1558..1587	CDD:279035
		RanBP2-type Zn finger	1562..1581	CDD:275375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1587..1609
		zf-RanBP	1617..1645	CDD:279035
		RanBP2-type Zn finger	1621..1640	CDD:275375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1648..1675
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1772
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1819..1846
		RanBD2_RanBP2-like	1864..1980	CDD:269998
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:P49792	1984..2124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2111..2144
		RanBD3_RanBP2-like	2161..2277	CDD:270204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2316..2348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2394..2430
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2443..2463
		IR1-M	2468..2529	CDD:288995
		Interaction with sumoylated RANGAP1. /evidence=ECO:0000250	2468..2472
		2 X 50 AA approximate repeats	2470..2596
		Required for E3 SUMO-ligase activity. /evidence=ECO:0000250	2470..2545
		Interaction with UBE2I. /evidence=ECO:0000250	2470..2522
		Interaction with SUMO1. /evidence=ECO:0000250	2523..2596
		IR1-M	2544..2602	CDD:288995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2598..2666
		RanBD4_RanBP2-like	2754..2870	CDD:269999	24/149 (16%)
		cyclophilin_ABH_like	2893..3051	CDD:238907	35/172 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810