DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and FAA2

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_010931.3	Gene:	FAA2 / 856734	SGDID:	S000000817	Length:	744	Species:	Saccharomyces cerevisiae

Alignment Length:	623	Identity:	136/623 - (21%)
Similarity:	227/623 - (36%)	Gaps:	154/623 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NKETQVWSGPPRPTVYD------HNTSVGQI-VFNSLRCWPTN----VIQITDDDGT--VLTNAD 63
            :|.|..|....|...|.      ||...|.: :.|:.|..|..    |:.|...:..  :||:..
Yeast   118 DKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPEWILTDLA 182

  Fly    64 MLAYA-TRIALFFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIV---QG 124
            ..||: |..||:         :.:|  .|:|.:::                |.:..|.::   ..
Yeast   183 CQAYSLTNTALY---------ETLG--PNTSEYIL----------------NLTEAPILIFAKSN 220

  Fly   125 LYSVTK--PKIMFI------DGPDYDRIKEITKEWSP-KLITLTGKVEGVTSIEDLVKPHPAEKI 180
            :|.|.|  |.:.|:      |...:|.::.:.:...| |..:|..|:. ..|:|.:.:.....||
Yeast   221 MYHVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKIT-FFSLEQVEQVGCFNKI 284

  Fly   181 YVPASLATGGDQIAVVLCSSGTAGLPKAVALSHRHIASTNSLCIST---------DVLYTSATI- 235
              ||...| .|.:..:..:|||.||||.|.:|||:|||..:...||         ..||....:
Yeast   285 --PAIPPT-PDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMCFLP 346

  Fly   236 ------------DWMTGFSI--------TVM--------------------NLTCGFTRIISRRT 260
                        |...||.|        ||:                    ....|....:.:.|
Yeast   347 LAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRFEAGIKNALDKST 411

  Fly   261 FSAETALYLVSKYKVTCLAM-APWQAYELFT--SPLATSEQLESLKI---AFVIGGWI-----SL 314
            .....|..::........|. .|.::...|.  ..:...:..:||.:   :|:|.|..     :|
Yeast   412 VQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGLSNNSFIITGSAPISKDTL 476

  Fly   315 ALLRRAQELLPKTYVMFSYGTTET--GVVTINIDHSLECSVGR-----LAPGMRIKIQGEDGQQL 372
            ..||.|.::    .:...||.|||  ||.   :....|..||.     ::...|:|...|.|...
Yeast   477 LFLRSALDI----GIRQGYGLTETFAGVC---LSEPFEKDVGSCGAIGISAECRLKSVPEMGYHA 534

  Fly   373 GVNQTGEVLIDIGLKWEGYLSNPEDTATTL-QDGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSK 436
            ..:..||:.|.....:|.|..||.:|:..: ||||.:.||:.:.|....:.::||.|:..|....
Yeast   535 DKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDGKGRISVIDRVKNFFKLAHG 599

  Fly   437 HY-WPNEIEQI-IAELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEI-ADQKVIDHVAQRVVVD 498
            .| .|.:||.| ::..|.:..:.|       :||.....::...|.:: |.|.::......|...
Yeast   600 EYIAPEKIENIYLSSCPYITQIFV-------FGDPLKTFLVGIVGVDVDAAQPILAAKHPEVKTW 657

  Fly   499 YKQLNAGVIFVDKFPKNANGKVMRSLAREVFEKTKPIT 536
            .|:     :.|:...:|      :.|.:|...|....|
Yeast   658 TKE-----VLVENLNRN------KKLRKEFLNKINKCT 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	131/607 (22%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	120/558 (22%)
FAA2	NP_010931.3	LC-FACS_euk	126..734	CDD:341250	133/615 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930