DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and PCS60

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_009781.3	Gene:	PCS60 / 852523	SGDID:	S000000426	Length:	543	Species:	Saccharomyces cerevisiae

Alignment Length:	498	Identity:	115/498 - (23%)
Similarity:	186/498 - (37%)	Gaps:	121/498 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFIDGPDYD 142
            :|.|:.....|:.::|||      .||.....|.|..:..|       |.:..|:      .:|.
Yeast   117 KGTTKLQSSEILKSASTF------GCFIVELAFDATRFRVE-------YDIYSPE------DNYK 162

  Fly   143 RIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGLPK 207
            |:...:...:..:.|...|..|.....|                      :|::|.:|||...||
Yeast   163 RVIYRSLNNAKFVNTNPVKFPGFARSSD----------------------VALILHTSGTTSTPK 205

  Fly   208 AVALSHRHIASTNSLCISTDVLYTSATIDWMTGFSITVMNLTCGFTRIISRRTFSAETAL-YLVS 271
            .|.|.|.:|..:.....:|   |....:|    .|..||.|            |.....: .|:|
Yeast   206 TVPLLHLNIVRSTLNIANT---YKLTPLD----RSYVVMPL------------FHVHGLIGVLLS 251

  Fly   272 KYKVTCLAMAP--------WQAYELFTS------PLATSEQLESLK------IAFVIGGWISLAL 316
            .::.....:.|        |..:..:..      |..:...|...|      |.|:..  .|.||
Yeast   252 TFRTQGSVVVPDGFHPKLFWDQFVKYNCNWFSCVPTISMIMLNMPKPNPFPHIRFIRS--CSSAL 314

  Fly   317 LRRAQELLPKTY---VMFSYGTTETGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGV---- 374
            .......|.|.:   |:.:|..||.         |.:.:...|.||.|  ..|..||..||
Yeast   315 APATFHKLEKEFNAPVLEAYAMTEA---------SHQMTSNNLPPGKR--KPGTVGQPQGVTVVI 368

  Fly   375 ----------NQTGEVLI---DIGLKWEGYLSNPEDTAT--TLQDGWINLGDLGYFDEDNNLYLV 424
                      .:.|||.|   ::.|   ||.:||:....  |.::.:...||.||||.:..|.|.
Yeast   369 LDDNDNVLPPGKVGEVSIRGENVTL---GYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLT 430

  Fly   425 DRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVID 489
            .|.|:|:....:...|.|::.|:...|:::.....||.|..||....|.|:.|:|.::..:::::
Yeast   431 GRIKELINRGGEKISPIELDGIMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVN 495

  Fly   490 HVAQRVVVDYKQLNAGVIFVDKFPKNANGKVMRSLAREVFEKT 532
            .: ::.:..:| :...|.||||.||.|.||:.|.:..|.|.|:
Yeast   496 FL-KKHLASFK-IPTKVYFVDKLPKTATGKIQRRVIAETFAKS 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	114/495 (23%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	111/485 (23%)
PCS60	NP_009781.3	FACL_fum10p_like	18..531	CDD:341249	112/491 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810