Protein Alignment CG4563 and ACSS3

DIOPT Version :10

• Sequence 1: NP_611913.1
• Gene: CG4563 / 37901
• FlyBaseID: FBgn0035006
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 116/557 - (20%)
• Similarity: 209/557 - (37%)
• Gaps: 124/557 - (22%)

  Fly    51 ITDDDGTVLTNADMLAYATRIALFFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNY 115
            :|:...| .|..::|...:::|......|:.:.|.|.|...    :||.|...........|::
Human   137 VTNTKAT-FTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMP----MIPQAMYTMLACARIGAIH- 195

  Fly   116 SREPAIVQGLYSV---------TKPKIMFIDGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDL 171
                :::.|.::.         .|||::            :|..:.   |....:||.|..:|:.
Human   196 ----SLIFGGFASKELSSRIDHVKPKVV------------VTASFG---IEPGRRVEYVPLVEEA 241

  Fly   172 VK--PHPAEKIYV-------PASLATGGD-----QIA----------------VVLCSSGTAGLP 206
            :|  .|..:||.:       ...||.|.|     ::|                .:|.:|||.|||
Human   242 LKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLP 306

  Fly   207 KAV--------ALSHRHIASTNSLCISTDVLYTSATIDWMTGFS-ITVMNLTCGFTRII--SRRT 260
            |.|        .:.|..::|...| ...:|.:.::.:.|:.|.| |....|..|.|.::  .:..
Human   307 KGVIRPTGGYAVMLHWSMSSIYGL-QPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPV 370

  Fly   261 FSAETALYLVSKYKVTCLAMAPWQAYELFTSP--------------LATSEQLESLKIAFVIGGW 311
            .:.:...|    ::|    :|......|||:|              |.....|...|..||.|..
Human   371 GTPDAGAY----FRV----LAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGER 427

  Fly   312 ISLALLRRAQELLPKTYVMFSYGTTETG----VVTINIDHSL---ECSVGRLAPGMRIKIQGEDG 369
            ..:..|..::.:. :..|:..:..||||    ...:.:.:|.   ....|:..||..:.|..::.
Human   428 CDVETLEWSKNVF-RVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNM 491

  Fly   370 QQLGVNQTGEVLIDIGL---KWEGYLSNPEDTATTLQD---GWINLGDLGYFDEDNNLYLVDRKK 428
            |:|.....|.:::.:.|   .:.|...|.|.......:   |:.:..|.||.||:..||::.|..
Human   492 QKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVD 556

  Fly   429 DLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQ 493
            |::...........||:.|.....|....|||..|...|....||.:.::.....:::|::.:.:
Human   557 DVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVK 621

  Fly   494 RVVVDYKQLNAG-------VIFVDKFPKNANGKVMRS 523
            .|     :.|.|       .:||.:.||..:||:.||
Human   622 HV-----RQNIGPVAAFRNAVFVKQLPKTRSGKIPRS 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:341237	114/553 (21%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	116/557 (21%)