DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and Slc27a5

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_077057.1	Gene:	Slc27a5 / 79111	RGDID:	708535	Length:	690	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	128/574 - (22%)
Similarity:	219/574 - (38%)	Gaps:	123/574 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TDDDGTVLTNADMLAYATRIALFFKS---EGLTQEDR----VGIIANSSTFVIPVATACFFQATP 109
            |..:|..:||.::.|.|.:.|...|:   |...|||:    :.::.:.|...:.|.........|
  Rat   136 TGSEGCSITNRELNAKACQAAWALKAKLKEATIQEDKGATAILVLPSKSISALSVFLGLAKLGCP 200

  Fly   110 FHAVN-YSREPAIVQGLYSVTKPKIMFIDGPDYDRIKEITKEWSPKLI------------TLTGK 161
            ...:| :||...::..:.| :...::.:| ||   ::|..:|..|||:            :.|..
  Rat   201 VAWINPHSRGMPLLHSVQS-SGASVLIVD-PD---LQENLEEVLPKLLAENIRCFYLGHSSPTPG 260

  Fly   162 VEGVTSIEDLVKPHPAEKIYVPASLATG--GDQIAVVLCSSGTAGLPKAVALSHRHI---ASTNS 221
            ||.:.:..|.....|     |||.|...  ....|:.:.:|||.||||...|||..:   ::..|
  Rat   261 VEALGAALDAAPSDP-----VPAKLRANIKWKSPAIFIYTSGTTGLPKPAILSHERVIQMSNVLS 320

  Fly   222 LCIST--DVLYTSATIDWMTGFSITVMN-LTCGFTRIISRRTFSAETALYLVSKYKVTCLAMAPW 283
            .|..|  ||:|....:....|..:.|:. |..|.|.:::.: |||       |:|...|
  Rat   321 FCGRTADDVVYNVLPLYHSMGLVLGVLGCLQLGATCVLAPK-FSA-------SRYWAEC------ 371

  Fly   284 QAYELFTSPLATSEQLESL------------KIAFVIGGWISLALLRRAQELLPKTYVMFSYGTT 336
            :.|.: |..|...|.|..|            .:.|.:|..:...:....|:......:...||:|
  Rat   372 RQYSV-TVVLYVGEVLRYLCNVPGQPEDKKHTVRFALGNGLRADVWENFQQRFGPIQIWELYGST 435

  Fly   337 ETGVVTIN-IDH-----SLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIG---------- 385
            |..|..:| :.|     ...|.:..|.|...::...|..:.:...|...:.::.|
  Rat   436 EGNVGLMNYVGHCGAVGKTSCFIRMLTPLELVQFDIETAEPVRDKQGFCIPVETGKPGLLLTKIR 500

  Fly   386 --LKWEGYLSNPEDTATTL-------QDGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPN 441
              ..:.||..:.::|...|       .|.:.|.||:...|::...|..||..|..::|.::....
  Rat   501 KNQPFLGYRGSQDETKRKLVANVRQVGDLYYNTGDVLALDQEGFFYFRDRLGDTFRWKGENVSTR 565

  Fly   442 EIEQIIAELPEVEHVCVVGVR----DARYGDAAGALIIKKEGAEIADQKVIDHV----------- 491
            |:|.:::.|..:|.|.|.||.    :.:.|.||..|   ..|.....||:..||
  Rat   566 EVEGVLSILDFLEEVNVYGVTVPGCEGKVGMAAVKL---APGKTFDGQKLYQHVRSWLPAYATPH 627

  Fly   492 ------AQRVVVDYK----QL-----NAGVIFVDKFPKNANGKVMRSLAREVFE 530
                  :..:...||    ||     :.|||....:..:...:..|||..:|::
  Rat   628 FIRIQDSLEITNTYKLVKSQLAREGFDVGVIADPLYILDNKAETFRSLMPDVYQ 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	128/574 (22%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	124/563 (22%)
Slc27a5	NP_077057.1	PRK08279	101..690	CDD:236217	128/574 (22%)
Slc27a5	NP_077057.1	AFD_class_I	140..680	CDD:302604	126/567 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930