DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and acsf2

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001038884.2	Gene:	acsf2 / 751707	ZFINID:	ZDB-GENE-060825-7	Length:	606	Species:	Danio rerio

Alignment Length:	594	Identity:	127/594 - (21%)
Similarity:	215/594 - (36%)	Gaps:	122/594 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PPRPTVYDH--------NTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIALFFKS 77
            |...|.|.|        :::|.|.:..::..:|.....:...||...|.|:......:.|....:
Zfish    48 PTLTTSYVHGLSSHPLQSSTVDQCLQATVERYPDREAMVFVQDGIRKTFAEFYQDVEKAAAGLLA 112

  Fly    78 EGLTQEDRVGI------------IANSSTFVIPVATACFFQ------------------ATPFHA 112
            .||.:.||:|:            .|.:...:|.||....:|                  .|.|.:
Zfish   113 AGLKRGDRLGMWGPNIYEWVLMQFATAKAGIILVAVNPAYQLQEVEFALRKVQCNAVVCPTKFKS 177

  Fly   113 VNY---------SREPAIVQGLYSVTKPKIMFIDGPDYDRIKEITKEWSP-----KLITLTGKVE 163
            .:|         ..|.|...|:.|...|.:..:         .:|....|     |.:...|..:
Zfish   178 QHYCDMLKQLCPEMETASPGGIKSSRLPDLHTV---------IVTDSQQPGSFLLKDLMQAGSSQ 233

  Fly   164 GVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGLPKAVALSHRHIASTNSLCISTDV 228
            ....::||.|....:            |.|.:.. :|||.|.||...|||.:|.:        :.
Zfish   234 HYQQLQDLQKKLVCD------------DPINIQF-TSGTTGKPKGATLSHHNIVN--------NA 277

  Fly   229 LYTSATI--DWMTGFSIT---------------VMNLTCGFTRIISRRTFSAETALYLVSKYKVT 276
            .:|...|  :|.....|.               |:....|.|.|.....:.....|..:.|.|.|
Zfish   278 YFTGMRIGYNWRKNVRICLPVPLYHCFGSVGGGVIMALYGTTVIFPSTGYDGRANLRAIEKEKCT 342

  Fly   277 CLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLPKTYVMFSYGTTETGVV 341
            .:...|....::...|......|.|::.....|......::|:...::....::..|||||...|
Zfish   343 FVYGTPTMYIDMLGQPDLAKFDLSSVRGGIAAGSPCPPEVMRKILNVMGIKEMVIGYGTTENSPV 407

  Fly   342 TI------NIDHSLECSVGRLAPGMRIK-IQGEDGQQLGVNQTGEVLIDIGLKWEGY---LSNPE 396
            |.      :.:..:| :||.::|....| :....|:.:.:...||::|      .||   |...:
Zfish   408 TFCGFPVDSAERKIE-TVGCISPHTEAKVVDPTTGEIVPLGAQGELMI------RGYCVMLEYWQ 465

  Fly   397 DTATT----LQDGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVC 457
            |...|    .:|.|...||:...|:.....:..|.|||:....::.:|.||||.:...|::....
Zfish   466 DEEKTRECITKDRWYKTGDIASLDQFAYCKIEGRIKDLIIRGGENIYPAEIEQFLHTHPKILEAQ 530

  Fly   458 VVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGKVMR 522
            ||||:|.|.|:...|.|..|||.|...:::..:...: :..|| :...::||..:|....||:.:
Zfish   531 VVGVKDERMGEEVCACIRLKEGQECTVEEIKAYCKGK-IAHYK-VPRYILFVQDYPLTITGKIQK 593

  Fly   523 SLAREVFEK 531
            ...||..||
Zfish   594 HKLRERTEK 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	125/592 (21%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	116/546 (21%)
acsf2	NP_001038884.2	PRK08315	53..606	CDD:236236	125/589 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810