DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and DIP2B

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	640	Identity:	129/640 - (20%)
Similarity:	220/640 - (34%)	Gaps:	182/640 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VGQIVFNSL---------------RCWPTNVI-QITDDDGTVLTNADMLAY---ATRIALFFKSE 78
            :|||..|.|               :..|.:|: .:.:..||.:..|..|..   |.|||.....:
Human   976 LGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDK 1040

  Fly    79 G-LTQEDRVGIIANSSTFVIPVATACFF------QATPFHAVNYSREPAIVQGLYSVTKPKIMFI 136
            | |...|.|.::......:|.....|.:      ...|.||.|.:.....|:.:..|:|...:..
Human  1041 GHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILT 1105

  Fly   137 DGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPA------------EKIYVPASLATG 189
                           |..|:.|....|...:::  ||..|.            .::|.|.:
Human  1106 ---------------SQTLMRLLRSREAAAAVD--VKTWPTIIDTDDLPRKRLPQLYKPPT---- 1149

  Fly   190 GDQIAVVLCSSGTAGLPKAVALSHRHIASTNSLCISTDV---LYTSATI----DWMTGFSITVMN 247
            .:.:|.:..|..|.|:...|.:||   ::.|:||.:..:   ||:|..|    |...|....:..
Human  1150 PEMLAYLDFSVSTTGMLTGVKMSH---SAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWC 1211

  Fly   248 LTCGFT--RIISRRTFSAETALYL----VSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAF 306
            |...::  :.:.......|..|:|    |::||:.. ....:...||.|..|  ..|:|.||..
Human  1212 LCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRD-TFCSYSVMELCTKGL--GNQVEVLKTR- 1272

  Fly   307 VIGGWISLALLRR---AQELLPKTYVMFSY-----------------------------GTTETG 339
                .|:|:.:|.   ..|..|:..:..|:                             ||:...
Human  1273 ----GINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPD 1333

  Fly   340 VVTINID-----HS-------------LECSVGRLAPGMRIKI-QGEDGQQLGVNQTGEVLIDIG 385
            ..|:.:|     |.             |....|::.||:::.| ..|....:|.:..||:.::..
Human  1334 PTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSP 1398

  Fly   386 LKWEGYLSNPE----------------DTATTLQDGWINLGDLGYF----------DEDNNLYLV 424
            ....||.:..:                |.|.||   |...|.||:.          :..:.||:|
Human  1399 HTASGYYTIYDSETLQADHFNTRLSFGDAAQTL---WARTGYLGFVRRTELTAATGERHDALYVV 1460

  Fly   425 DRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALIIKKE--GAEIADQKV 487
            ....:.|:.:...|.|.:||..::.:......|.|..       ....|::..|  |:|   |:.
Human  1461 GALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFT-------WTNLLVVVVELCGSE---QEA 1515

  Fly   488 IDHV--AQRVVVDYKQLNAGVIFV---DKFPKNANGKVMRSLAREVF--EKTKPI 535
            :|.|  ...||::...|..||:.|   ...|.|:.|:..|...|:.|  ::..||
Human  1516 LDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPI 1570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	127/634 (20%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	117/591 (20%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	97/509 (19%)
		AFD_class_I	1012..1565	CDD:302604	120/597 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900