DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and CG11659

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	193/517 - (37%)
Similarity:	301/517 - (58%)	Gaps:	7/517 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIALFF 75
            ::.:.::|||.|....:|.:.|:|:|:|:.:|..|....||:..:|||||..::||.|.|:|.:.
  Fly     9 YDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYM 73

  Fly    76 KSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFIDGPD 140
            :|.||.|.|.||:|..::|.::.||.||||....||::|.:.:...::.:|.||:|.|:|.||.:
  Fly    74 RSLGLLQSDIVGLIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSIIFCDGDE 138

  Fly   141 YDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGL 205
            :::::..|.|...|::|:.........|:::|.. |.|:.:.||.|..|.||...:||||||.|.
  Fly   139 FEKVRSATAELDVKIVTMRNHPLDSIKIDEVVAT-PIEENFQPAKLEKGNDQTLAILCSSGTTGT 202

  Fly   206 PKAVALSH-RHIASTNSLCISTDVLYTSATIDWMTGFSITVMNLTCGFTRIISRRTFSAETALYL 269
            ||||.::: |||.:.|....:.||.|:..|:||:||...|:.:.....||||:...|....||.:
  Fly   203 PKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIADNAFDPAFALRI 267

  Fly   270 VSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLPKTYVMFSYG 334
            :.:||||.....|.....:...|...:..|.||:.....|...:|.:.:..:..|....:.|.||
  Fly   268 IEEYKVTWTIQPPSSMALMINCPDFETCDLSSLRCYMFGGSRAALEVQKGIRSRLSHNCLQFVYG 332

  Fly   335 TTETG-VVTINIDHSLEC-SVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIGLKWEGYLSNPED 397
            .||.| :.|||.....:. |||:|..|:::||:.:||:.||.::.|||.|.....|.||..|..:
  Fly   333 FTELGAMATINCHFDEKTGSVGQLVNGLKMKIKNDDGESLGPDEIGEVCIMNNQHWSGYYGNEVE 397

  Fly   398 TATTLQD--GWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVG 460
            | ..::|  ||.:.|||||.|.|..||::||||::|||::..|:||:||.:|:|:|:|..|||.|
  Fly   398 T-RNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVCVFG 461

  Fly   461 VRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGKVMR 522
            :....:||.|.|.::||.|:|:..|.|:|:|..|....|||||.|.:.||...::||||..|
  Fly   462 IWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQRSANGKTNR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	190/507 (37%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	181/476 (38%)
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	188/498 (38%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	181/476 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471305
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	10	9.860