DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and CG4830

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	223/524 - (42%)
Similarity:	325/524 - (62%)	Gaps:	3/524 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PTFFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIA 72
            |..::.|.::|.|.|:...:...||:|:|:|.::|.||.||.||:|.:|..:|....|.:|.|||
  Fly     5 PCSYDAENKIWKGIPQNNPFKPETSLGRIIFKNMRNWPKNVCQISDSEGVEVTFGQALTWAIRIA 69

  Fly    73 LFFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFID 137
            ...||.||..:|.:||.|.::|:::|.|.||||..|||.:.|...|.:.::.||:::||||:|.|
  Fly    70 QQLKSRGLDHKDIIGISARNTTYIMPTAVACFFHGTPFQSANPILEESTLKHLYNISKPKIIFTD 134

  Fly   138 GPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGT 202
            ...||::...|..:.|::|..||..:||.||:||:.|...|..|.|..|..|..|...:|.||||
  Fly   135 ADHYDKLYSATSAFKPEIILTTGTKDGVLSIQDLLAPTKTEFFYQPTPLKEGPSQTVAILTSSGT 199

  Fly   203 AGLPKAVALSHRHIASTNSLCISTDVLYTSATIDWMTGFSITVMNLTCGFTRIISRRTFSAETAL 267
            .|:||||.:|:..:..........|.::.||::||:||...|:.:...|.|||||.:.|:|:..:
  Fly   200 TGMPKAVCISNDILTQETVFVNGYDTIFISASLDWITGLWATIFSTVNGCTRIISSKPFAADYFV 264

  Fly   268 YLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESL-KIAFVIGGWISLALLRRAQELLPKTYVMF 331
            ||||||.:|...:.|.....|...|.||.|:|.|| |:.|. ||.::.|.:.|.::|.|...:..
  Fly   265 YLVSKYSITYALIPPEHCCSLLDCPTATPEKLGSLTKLNFG-GGRMTQATVERVKKLAPNGVLNS 328

  Fly   332 SYGTTETGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIGLKWEGYLSNPE 396
            |||.||.|.:..|..|....:.|...||:::||..:||.|||||||||:::..|..|.||.::||
  Fly   329 SYGMTEVGFIVFNHGHLKLTAAGNPLPGIQVKIVDDDGNQLGVNQTGEIIVHNGFSWNGYFADPE 393

  Fly   397 DT-ATTLQDGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVG 460
            .| |...::||.:.||:||||||:.||:.||||::||:|....||.|:|.:|.|||||:.|||:|
  Fly   394 ATKAMQDEEGWFHTGDMGYFDEDDYLYMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIG 458

  Fly   461 VRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGKVMRSLA 525
            |.|...||..|||:::::.|.:..|:||||||:|:....|||.|||.|.|:.|:|.||||:|..|
  Fly   459 VYDETQGDVPGALVVREDNATLTAQQVIDHVAKRLPDIQKQLRAGVQFADEIPQNHNGKVVRRYA 523

  Fly   526 REVF 529
            |::|
  Fly   524 RDLF 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	219/511 (43%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	203/473 (43%)
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	219/511 (43%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	202/472 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471303
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I5120
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	11	10.910