DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and CG5568

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	183/534 - (34%)
Similarity:	297/534 - (55%)	Gaps:	11/534 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAVFPT--FFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLA 66
            |:.|.|  .|::..::|||..:.:::..:.|:|:|:|..:........||:..:.|.||..|:..
  Fly     8 KSPFKTRNTFDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTWKDIQT 72

  Fly    67 YATRIALFFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKP 131
            .|.::|.:.:..||.|.|.||:|...:|.:..:|.||||..||:||::...|.:.::.|:.:|||
  Fly    73 NAMKVASYMRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQSAIERLFGITKP 137

  Fly   132 KIMFIDGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVV 196
            :::|.||.::::::..||....:::|:.....|:..|:|::.. |.|..:.|..|..|.||:..:
  Fly   138 RLIFCDGDEFEKVQAATKGLQVQIVTMRNHPAGILRIQDILTT-PVEMNFRPVRLKDGTDQLLAI 201

  Fly   197 LCSSGTAGLPKAVALSHRHIASTNSLCISTDVL-YTSATIDWMTGFSITVMNLTCGFTRIISRRT 260
            |.||||:||||||.:|:.|....:.|.:.:.:: |...|:||.:|.::|:.......|.||....
  Fly   202 LSSSGTSGLPKAVTISNSHQIIGSFLPVDSSIIQYNPNTLDWASGITMTINAAVFSLTSIIEDCD 266

  Fly   261 FSAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLP 325
            |.......|:.||:::.:.::..|...|...|...:..|.|:|..|..|...||.:..:.:..|.
  Fly   267 FDPANLCGLIEKYRISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLS 331

  Fly   326 KTYVMFSYGTTE---TGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIGLK 387
            ...|.|||..||   .|.:..|.|.... ||||...|::|||..|.|:..|.|..||:..:.|.|
  Fly   332 NECVNFSYTLTELNSPGCLNFNFDEKPN-SVGRPVRGIQIKIVNELGEAQGPNVVGEICFNNGQK 395

  Fly   388 WEGYLSNPEDTATTLQD--GWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAEL 450
            |.||..|||:| ..:||  .|.:.|||||.|||..|:::||.||:|||::..|:|:|||.:|||:
  Fly   396 WPGYYKNPEET-KKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEM 459

  Fly   451 PEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKN 515
            |.|...||.|:.|..|||.|.|.::||:|.::..|.|:::|.:|:...:||||.|.:.||...::
  Fly   460 PNVVEACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVDHIIQS 524

  Fly   516 ANGKVMRSLAREVF 529
            .|.|..|:..:..|
  Fly   525 GNRKANRAATKAEF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	176/515 (34%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	170/477 (36%)
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	176/507 (35%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	170/477 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471306
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	10	9.860