DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and CG9993

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	167/547 - (30%)
Similarity:	273/547 - (49%)	Gaps:	29/547 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TFFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIAL 73
            |.::...::||||.....|..:.::|::....||.:...|:|:.|..|..||.:.:|..:.|:|.
  Fly     4 TKYDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAH 68

  Fly    74 FFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFIDG 138
            .|:...|.:.|.|||.|.::|::..|..|.....||.:.::...:......::.:||||::|.|.
  Fly    69 AFQRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDL 133

  Fly   139 PDYDRIKEI--TKEWSPKLITLTGKVEGVTSIEDLVKP----HPAEKIYVPASLATGGDQIAVVL 197
            .:|..:..:  :.::..::|.|||.:.||.:|:||:..    :..:.::....|.  ||..|.::
  Fly   134 DNYQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGCTGYDEKTLFACPHLC--GDDTAFII 196

  Fly   198 CSSGTAGLPKAVALSHRHI---ASTNSLCISTDVLYTSATIDWMTGFSITVMNLTCGFTRIISRR 259
            .|||..||||.|..|||.:   |....|..|..||:..:.:.|::.....:.:|..|..|||:.|
  Fly   197 TSSGVTGLPKGVTRSHRSLLNSAKIPQLFTSDTVLFCFSPLYWISCIFTLLASLVNGCRRIITNR 261

  Fly   260 TFSAETALYLVSKYKVTCLAMAPWQAYELFTSP----LATSEQLESLKIAFVI-GGWISLALLRR 319
            .||......||.:::|:.:...|.....|..||    ||...|...   :||. |..:.:.:.|:
  Fly   262 PFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQ---SFVCSGSKVPMGIWRQ 323

  Fly   320 AQELLPKTYVMFSYGTTETGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDI 384
            ..|||........||.||||.::.|:...|. |.|||...:::::....||.||.||||::|:.:
  Fly   324 LYELLGANRFAVLYGLTETGGISKNVGGPLG-SEGRLLRNVQVRVVDPHGQSLGPNQTGQILVRL 387

  Fly   385 GLKWEGYLSNPEDTATTL-QDG-WINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQII 447
            .|:|.||..||::|..|: .|| |:..||.||||::..|:...|..|:.||.....:|.:||.:|
  Fly   388 NLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVI 452

  Fly   448 AELPEVEHVCVVGVRDARYGDAAGALIIKKE---GAEIADQKVIDHVAQRVVVDYKQLNAGVIFV 509
            ..||.|..|.|.|:.|....:.....:::.|   ||::.:..|...|||. :.|...:..||.||
  Fly   453 LHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQH-LSDAFHIRGGVFFV 516

  Fly   510 DKFPKNANGKVMRSLAREVFEKTKPIT 536
            |..||..|.||.|   |:::.:....|
  Fly   517 DNLPKTQNSKVQR---RKIWSQLSEAT 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	162/528 (31%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	153/490 (31%)
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	161/520 (31%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	153/489 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860