DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and ACSM2B

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001098539.1	Gene:	ACSM2B / 348158	HGNCID:	30931	Length:	577	Species:	Homo sapiens

Alignment Length:	531	Identity:	115/531 - (21%)
Similarity:	192/531 - (36%)	Gaps:	149/531 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GLTQEDRVGIIANSSTFVIP----VATACFFQATPF-------------HAVNYSREPAIVQGLY 126
            ||.:.|||.::...    :|    |...|......|             :.:..|:..|||.|..
Human   102 GLQRGDRVAVMLPR----VPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDE 162

  Fly   127 SVTKPKIMFIDGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGD 191
            .:.:...:..:.|.. |||.:..|.|         .:|..:.:.|:.    |.......:.||..
Human   163 VIQEVDTVASECPSL-RIKLLVSEKS---------CDGWLNFKKLLN----EASTTHHCVETGSQ 213

  Fly   192 QIAVVLCSSGTAGLPK-------AVALSHRHIASTNSLCISTDVLYTSATIDWMTGFSITVMNLT 249
            :.:.:..:|||:||||       ::.|..:..|....|..| |:::|.:...|       ::|:
Human   214 EASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQAS-DIMWTISDTGW-------ILNI- 269

  Fly   250 CGFTRIISRRTFSAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISL 314
              ...::...|..|.|.::|:.|:                 .||...:.|.|..|..::|..|..
Human   270 --LGSLLESWTLGACTFVHLLPKF-----------------DPLVILKTLSSYPIKSMMGAPIVY 315

  Fly   315 ALLRR-----------------AQELLPKTY----------VMFSYGTTETGVVTINIDHSLECS 352
            .:|.:                 .:.|||:|.          :...||.||||         |.|.
Human   316 RMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYGQTETG---------LTCM 371

  Fly   353 VG---RLAPGMR--------IKIQGEDGQQLGVNQTGEVLIDIGLK---------WEGYLSNPED 397
            |.   ::.||..        :::..:.|..|.....|    |||::         :.||:.||:.
Human   372 VSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEG----DIGIRVKPIRPIGIFSGYVENPDK 432

  Fly   398 TATTLQ-DGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGV 461
            ||..:: |.|: |||.|..|||.....:.|..|::........|:|:|..:.:.|.|....|:..
Human   433 TAANIRGDFWL-LGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISS 496

  Fly   462 RDARYGDAAGALIIKKEGAEIADQ----------KVIDHVAQRVVVDYKQLNAGVIFVDKFPKNA 516
            .|...|:...|.:|      :|.|          |.:....:.|...||.... :.||...||..
Human   497 PDPVRGEVVKAFVI------LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK-IEFVLNLPKTV 554

  Fly   517 NGKVMRSLARE 527
            .||:.|:..|:
Human   555 TGKIQRTKLRD 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	115/531 (22%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	113/523 (22%)
ACSM2B	NP_001098539.1	AFD_class_I	40..568	CDD:388389	115/531 (22%)
		Coenzyme A binding. /evidence=ECO:0000250	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000250	540..542		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920