DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and Acsf3

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_659181.2	Gene:	Acsf3 / 257633	MGIID:	2182591	Length:	583	Species:	Mus musculus

Alignment Length:	568	Identity:	128/568 - (22%)
Similarity:	224/568 - (39%)	Gaps:	116/568 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DGTVLTNADMLAYATRIALFFK--------------------------SEGLTQEDRVGIIANSS 93
            ||:|......||:..||||..|                          ..|..||:||..:.::.
Mouse    41 DGSVPVFIRALAFGDRIALIDKYGHHTYRELYDRSLCLAQEICRLQGCKVGDLQEERVSFLCSND 105

  Fly    94 TFVIPVATACFFQ---ATPFHAVNYSREPAIVQGLYSVTKPKIMFIDGPDY-DRIKEITKEWSPK 154
            ...:....|.:..   |.|.    |.:.|......:.......:.:.|.:| :|:..:.:.....
Mouse   106 VSYVVAQWASWMSGGVAVPL----YWKHPEAQLEYFIQDSRSSLVVVGQEYLERLSPLAQRLGVP 166

  Fly   155 LITLTGKV-EGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGLPKAVALSHRHIAS 218
            |:.||..| .|.|.       .|.|:   |...:...|:.|::..:|||.|.||....:||::|:
Mouse   167 LLPLTPAVYHGATE-------KPTEQ---PVEESGWRDRGAMIFYTSGTTGRPKGALSTHRNLAA 221

  Fly   219 TNSLCI------STDVLYTSATIDWMTGFSITVMNLTC----GFTRIISRRTFSAETA--LYLVS 271
            ..:..:      ..||:.....:..:.|   .|..|.|    |.|.::... |||:..  .:|.|
Mouse   222 VVTGLVHSWAWTKNDVILHVLPLHHVHG---VVNKLLCPLWVGATCVMLPE-FSAQQVWEKFLSS 282

  Fly   272 KYKVTCLAMAPWQAY--------ELFTSP------LATSEQLESLKIAFVIGGWISL--ALLRRA 320
            :.....:.||....|        :.||.|      .|..::    :|..::.|..:|  .||.:.
Mouse   283 EAPQITVFMAVPTVYSKLLDYYDKHFTQPHVQDFVRAVCKE----RIRLMVSGSAALPVPLLEKW 343

  Fly   321 QELLPKTYVMFSYGTTETGVVTIN--IDHSLECSVGRLAPGMRIKIQGE------------DGQQ 371
            :.....| ::..||.||.|:...|  .:..:..|||...||:.::|..|            :|.:
Mouse   344 RSATGHT-LLERYGMTEIGMALSNPLTEARVPGSVGTPLPGVEVRIISENPQKGSPYIIHAEGNE 407

  Fly   372 LGVNQT-------GEVLIDIGLKWEGYLSNPEDTATTL-QDGWINLGDLGYFDEDNNLYLVDRKK 428
            .|...|       ||:|:.....:..|...||:|.:.. .|||...||...| :|...::..|..
Mouse   408 RGTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKSAFTSDGWFRTGDTAVF-KDARYWIRGRTS 471

  Fly   429 -DLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEIA--DQKVIDH 490
             |::|.........|||:.:...|.:..|.|:||.|..:|....|::..:||..::  |.|   .
Mouse   472 VDIIKTGGYKVSALEIERHLLAHPSITDVAVIGVPDMTWGQRVTAVVALQEGHSLSHGDLK---E 533

  Fly   491 VAQRVVVDYKQLNAGVIFVDKFPKNANGKV-MRSLAREVF---EKTKP 534
            .|:.|:..| .:.:.::.|::.|:|..||| .:.|.::::   ::::|
Mouse   534 WARGVLAPY-AVPSELLLVEEIPRNQMGKVNKKELLKQLYPSGQRSQP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	127/563 (23%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	126/550 (23%)
Acsf3	NP_659181.2	MCS	55..569	CDD:341264	122/541 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900