DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4563 and Acsm3

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_006230168.1	Gene:	Acsm3 / 24763	RGDID:	62086	Length:	581	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	138/577 - (23%)
Similarity:	237/577 - (41%)	Gaps:	101/577 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAVFPTFFNKETQV---WSGPPRPTVYDHNT-SVGQIVFNSLRCWPTNVIQITDDDG-TVLTNAD 63
            |...|.:||....|   |:          || ..|:.:.|....|       .|.:| .|..:.:
  Rat    45 KIEIPEYFNFAKDVLDQWT----------NTEKTGKRLSNPAFWW-------VDGNGKEVRWSFE 92

  Fly    64 MLAYATR--IALFFKSEGLTQEDRVGII---------AN-----SSTFVIPVATACFFQATPFHA 112
            .|...:|  ..:..::..|.:.|||.:|         ||     :.|.:||..|    |.|
  Rat    93 ELGSLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTT----QLT---- 149

  Fly   113 VNYSREPAIVQGLYSVTKPKIMFID---GPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKP 174
                 :..|:..|.| :|.|.:..|   .|..|.:....:....|||......||..::::::|
  Rat   150 -----QKDILYRLQS-SKSKCIITDDTLAPAVDIVAAKCENLHSKLIVSQHSREGWGNLKEMMK- 207

  Fly   175 HPAEKIYVPAS---LATGGDQIAVVLCSSGTAGLPKAVALSHRHIA---STNSL----CISTDVL 229
                  |...|   :.|..:::..:..:|||.|.||.:..:|....   |.|..    .|::||:
  Rat   208 ------YASDSHTCVDTKHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVM 266

  Fly   230 YTSATIDWMTGFSITVMNL----TCGFTRIISRRTFSAETALYLVSKYKVTCLAMAPWQAYELFT 290
            :.::...|......:|.:.    .|.|...:.|  |.:.:.|..:||:.:|....||.....|..
  Rat   267 WNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPR--FDSTSILQTLSKFPITVFCSAPTAYRMLIQ 329

  Fly   291 SPLATSEQLESLKIAFVIGGWISLALLRRAQELLPKT--YVMFSYGTTETGVVTINIDHSLEC-- 351
            :.:..|.:..|||.....|..|:..::.:.::   ||  .:...||.|||.::..|. ..::.
  Rat   330 NDITRSYKFNSLKHCVSAGEPINPEVMEQWKK---KTGLDIYEGYGQTETVLICGNF-KGMKIKP 390

  Fly   352 -SVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDI------GLKWEGYLSNPEDTATTLQDGWINL 409
             |:|:.:|...::|..|:|..|...|.|::.:.:      || :..|:.||..||:||:..:...
  Rat   391 GSMGKPSPAFNVEILDENGTILPPGQEGDIAVQVLPDRPFGL-FTHYVDNPSKTASTLRGNFYIT 454

  Fly   410 GDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALI 474
            ||.||.|||...:.|.|..|::........|.|:|..:.|.|.:....||...|...|:...|.|
  Rat   455 GDRGYMDEDGYFWFVARSDDVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFI 519

  Fly   475 IKKEGAEIADQ-----KVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGKVMRSLAR 526
            :.....::.||     ::.:|| ::....||.... :.|:::.||..:|||.|:..|
  Rat   520 VLNPDYKLHDQEQLKKEIQEHV-KKTTAPYKYPRK-IEFIEELPKTVSGKVKRNELR 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	132/557 (24%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	124/521 (24%)
Acsm3	XP_006230168.1	Acs	45..575	CDD:223442	138/577 (24%)
Acsm3	XP_006230168.1	AFD_class_I	48..578	CDD:302604	137/574 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010