Protein Alignment CG4563 and ACSL1

DIOPT Version :10

• Sequence 1: NP_611913.1
• Gene: CG4563 / 37901
• FlyBaseID: FBgn0035006
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001986.2
• Gene: ACSL1 / 2180
• HGNCID: 3569
• Length: 698
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 118/567 - (20%)
• Similarity: 211/567 - (37%)
• Gaps: 147/567 - (25%)

  Fly    72 ALFFKSEGLTQEDRVGIIANSSTFVIPVATACFFQA---TPFH------AVNYSREPAIVQGLYS 127
            ||..|......:..:||.|.:....:.:...||..:   .|.:      |:.|         :.:
Human   136 ALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITY---------IVN 191

  Fly   128 VTKPKIMFIDGPDYDR--IKEITKEWSP--KLITLTG---------------KVEGVTSIEDL-- 171
            ..:..::|:|.|:..:  ::.:..:..|  |:|.:..               :|..:.::|||
Human   192 KAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGR 256

  Fly   172 ---VKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGLPKAVALSHRHIASTNSLCI-STDVLYTS 232
               .||.|      ||.     :.:||:..:|||.|.||...::||:|.|..|..: :|:.....
Human   257 ANRRKPKP------PAP-----EDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNP 310

  Fly   233 ATIDWMTGFSITVMNLTCGFTRII--------SRRTFSAETALYLVSKYKV---TCLAMAP---- 282
            ...|.:..|    :.|...|.|::        ::..|.......|:...||   |...:.|
Human   311 CPDDTLISF----LPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN 371

  Fly   283 ----------------W--------QAYELFTSPLATSEQLESL---KIAFVIGGWISLALLRRA 320
                            |        :..||.:..:..:...:.|   |:...:||.:.|.:...|
Human   372 RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAA 436

  Fly   321 QELLPKTYVMF-----------SYGTTETGV---VTINIDHSLECSVGRLAPGMRIK-IQGEDGQ 370
            .  :..|.:.|           .||.||...   :|:..|.:.. .||...|...|| :..|:..
Human   437 P--VSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAG-HVGAPMPCNLIKLVDVEEMN 498

  Fly   371 QLGVNQTGEVLIDIGLKWEGYLSNPEDTATTL-QDGWINLGDLGYFDEDNNLYLVDRKKDLLKYK 434
            .:.....|||.:.....::|||.:|..||..| :|||::.||:|.:..:..|.::||||.:.|..
Human   499 YMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLA 563

  Fly   435 SKHY-WPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVD 498
            ...| .|.:||.|......|..|.|       :|::..|.:|   ...:.|.:.:...||:...:
Human   564 QGEYIAPEKIENIYMRSEPVAQVFV-------HGESLQAFLI---AIVVPDVETLCSWAQKRGFE 618

  Fly   499 --YKQLNAGVIFVDKFPKNANGKVMRSLAR-------EVFEKTKPIT 536
              :::|...        |:....::..:.|       :.||:.|.||
Human   619 GSFEELCRN--------KDVKKAILEDMVRLGKDSGLKPFEQVKGIT 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:341237	112/543 (21%)
ACSL1	NP_001986.2	LC-FACS_euk	116..694	CDD:341250	118/567 (21%)