DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and acs-9

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_510728.2	Gene:	acs-9 / 188659	WormBaseID:	WBGene00020634	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	131/545 - (24%)
Similarity:	230/545 - (42%)	Gaps:	103/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIALFFKSEGLTQEDRVGI 88
            |....|:..:..:|...:|       |....|..|:|..::....:::.......|::|.|.:.:
Worm     6 PETLFHDLILENVVKFGIR-------QALVHDNQVITFEEIPQLVSKLVYKLLELGISQGDTILV 63

  Fly    89 -IANSSTFVIPVATACFFQATPFHAV--NYSREPAIVQGLYSVTK--PKIMF----IDGPDYDRI 144
             :.||..:.:     .|.......||  ..|.|....:..||:.:  .|::|    :...:|..:
Worm    64 CLPNSIWYPL-----LFLSCAKIGAVLSGISHESTAGEIKYSLKQSGAKLVFTNEKVSKENYWAL 123

  Fly   145 KEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGLPKAV 209
            .|.:.|..|.  ::...::.:|..||          :.|.:|..  |.|.:...||||.|.||..
Worm   124 SENSVEVLPD--SVKTYIDRITGHED----------FRPENLDI--DSILLAPFSSGTTGAPKCC 174

  Fly   210 ALSHRH-IASTNSL-------CISTDVLYTSATIDW--MTGFSITVMNLTCGFTRIISRRTFSAE 264
            .|:||: :|:|.||       .::...:.|.|.:.:  .:||...::.|..|.|..|... |...
Worm   175 LLTHRNFLAATYSLKKFLFDQLLAQSSMKTLAFLPFHHASGFWALLICLLEGCTTYIMSE-FHPI 238

  Fly   265 TALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALL------------ 317
            ..:.|:.||::..:.:.|         |:|..    .||:..:.|...||..:
Worm   239 VMMDLIEKYEIDTINIVP---------PIANI----FLKMGILQGRCPSLRTILCGSSGLQKDRC 290

  Fly   318 RRAQELLPK-TYVMFSYGTTETGVVTI------NIDHSLECSVGRLAPGMRIKIQGEDGQQLGVN 375
            :|...:.|: |:.:..||.||..|::.      |.:|...|  |.:.||...|        |..:
Worm   291 KRLLSIFPQVTHFIQGYGMTELVVLSCVTPFDDNFEHLGSC--GHILPGFETK--------LFEH 345

  Fly   376 QTGEVLIDIGLKWEGYLSNPEDTATTL-QDGWINLGDL-----GYFDEDNNLYLVDRKKDLLKYK 434
            .|||.  ::.||.:..:...::....| :|.|::.||:     |:|      |:|||.|||:|..
Worm   346 PTGET--ELWLKSDAIMKAYKNGTPNLDEDDWLHTGDIVTEKGGFF------YVVDRMKDLIKLN 402

  Fly   435 SKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGA-LIIKKEGAEIADQKVIDHVAQRVVVD 498
            .....|.|||.:|..||:|..|.|||:.|...|....| ::::|...|:...|.::|..:..:..
Worm   403 GYQVSPTEIENVILTLPKVAEVAVVGIEDELCGQLPKAYIVLEKNADELLFLKHLEHTMKEKLSA 467

  Fly   499 YKQLNAGVIFVDKFPKNANGKVMRS 523
            .|||..||..:.:.||:::||:.::
Worm   468 VKQLRGGVSIIKEMPKSSSGKIQKN 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	131/545 (24%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	127/516 (25%)
acs-9	NP_510728.2	CaiC	1..494	CDD:223395	131/545 (24%)
acs-9	NP_510728.2	Firefly_Luc_like	26..490	CDD:213279	126/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880