DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and acs-12

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_508035.1	Gene:	acs-12 / 180375	WormBaseID:	WBGene00009106	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	130/532 - (24%)
Similarity:	231/532 - (43%)	Gaps:	50/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIA---LFFKSEGLTQE 83
            |..|.:|       .:|:....:..:|..|.:|.....|..|::..|..||   ::.|.|   :.
Worm    13 PDKTFHD-------FLFHEWEKFREDVALIDNDTFAQFTFQDVMQKADFIAKSLVYLKVE---KS 67

  Fly    84 DRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFIDGP----DYDRI 144
            :.|.::.:.|...|.:|............|:...:...:|.....::.:.:|.| |    :.|::
Worm    68 EVVLLVMDWSPAAIYIALGASMAGAAIQVVSPKLQAWEMQFPVKESESRFVFSD-PLGLHEIDKL 131

  Fly   145 -KEITKEWSPKLITLTGK---VEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTAGL 205
             |.:.:|:.   |..||.   ..|...||||..   |.|..:|.........|..:..|||..|.
Worm   132 MKTLNREYR---IICTGSRDFANGYPIIEDLAF---AAKQNLPLPKIEPDTDIVYLPYSSGIHGK 190

  Fly   206 PKAVALSHRHIASTNSLCIST---------DVLYTSATIDWMTGFSITVMNLTCGFTRIISRRTF 261
            .|.:..:|:.:.:...:..:|         |...|...:....|....:..|..|.| :::.:.|
Worm   191 RKGIVTTHKVMVAKTMVMWNTSKHHEFRRGDTTLTMIPLHKQCGLDAILCALLNGLT-VVTEKNF 254

  Fly   262 SAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLP- 325
            ...|.:..:.:||:..:.:.|:....:.......:..:|||:........::..|.....|:.|
Worm   255 CVHTFMTCIQRYKIRAVHLTPYLMNLMMFEAENHTYNIESLEWVVTGADAVTEELYEEFTEIFPS 319

  Fly   326 -KTYVMFSYGTTETGVV--TINIDHSLECSVGRLAPGMRIKIQG-EDGQQLGVNQTGEVLIDIGL 386
             || |..:||.||.|::  |.|.::|..|  |:|...:.:|:.. ..|::||..:.|::.:. |:
Worm   320 VKT-VTQTYGMTEVGLICRTYNKNYSPSC--GQLTANLEMKVLDILTGKELGPREKGQICVK-GI 380

  Fly   387 KWEG-YLSNPEDTATTLQDGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAEL 450
            ..|. ||:||:.|.....|||...||:|:|||:.|::|||:.|:::|.......|.|||.::...
Worm   381 AAESPYLNNPKATEEHFLDGWRRTGDIGFFDEEGNVHLVDKLKEMIKVFGYQVIPKEIETLLLTH 445

  Fly   451 PEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKN 515
            ..||...||.:.:...|:...|.::.|:|....:..:.|:|.:| |:.||.| ..|......||:
Worm   446 QAVEEAAVVAINNELSGERPVAFVVLKKGFVATEDDLKDYVNKR-VIRYKHL-VRVNITQFLPKS 508

  Fly   516 ANGKVMRSLARE 527
            |.|.::|.|..|
Worm   509 ACGTLLRRLLAE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	130/532 (24%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	122/497 (25%)
acs-12	NP_508035.1	PLN02246	2..518	CDD:215137	128/528 (24%)
acs-12	NP_508035.1	Firefly_Luc_like	33..514	CDD:213279	122/497 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920