DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and C32E8.6

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_740831.1	Gene:	C32E8.6 / 171945	WormBaseID:	WBGene00016324	Length:	461	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	134/543 - (24%)
Similarity:	212/543 - (39%)	Gaps:	127/543 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIALF 74
            |.||...:|..             .:|.|.....:......:.|:..|..||      ..|||||
Worm    16 FENKTCLIWRD-------------REISFKEFHEYIGKWKNVLDEQKTKTTN------PLRIALF 61

  Fly    75 FKSEGLTQEDRVGIIAN---SSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFI 136
            ..:    ..|.:.||..   |...|||:        .|.:. .|..:..|.:.:.:.    |:..
Worm    62 CTN----SPDILAIIVAGQLSGVTVIPL--------NPSYK-KYEIDEYISKSIANF----IIVS 109

  Fly   137 DGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLA-TGGDQIAVVLCSS 200
            |..|.|:.:|.......:|.|     ..||                |:|.| |..:|..:|..||
Worm   110 DDVDLDKFEEREVNLISELFT-----SNVT----------------PSSTASTPENQGVIVFFSS 153

  Fly   201 GTAGLPKAVALSHRHIAS--TNSLCISTDVLYTSATID---------WMTGFSITVMNLT-CGFT 253
            ||.|.||....:.|.:.|  .....|.:|..:.|.:.|         :..|..||::::. .|.|
Worm   154 GTTGPPKQFEYTQRILCSQIDQIKAIRSDPRFFSPSTDDICYGVLPFFHAGGLITILSMIFSGCT 218

  Fly   254 RIISRRTFSAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLR 318
            .:|:.| ::....|.....|||:.|.:.|.........||.:|..|.:||..:|...........
Worm   219 VLINER-WNEHEFLANCQNYKVSVLFLVPPVLNFFANHPLVSSYDLSALKTIYVGAAASPPENFA 282

  Fly   319 RAQELLPKTYVMFS-YGTTETGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLI 382
            :..|.||:...:.. |||:|.||        |.||.|:             |:..| ...|....
Worm   283 KVAERLPELENLIQLYGTSECGV--------LLCSTGK-------------GKASG-KTVGWPFP 325

  Fly   383 DIGLKWEGYLSNPED------TATTLQDGWINLGDLGYFD-EDNNLYLVDRKKDLLKYKSKHYWP 440
            .:.||     .|||:      :||.:::|::..||||... :...|.:|.|.|:::|.:.....|
Worm   326 FVELK-----INPENNEIFVKSATAMEEGFMETGDLGCLSFKTIELMIVGRSKEMMKIRGWQVNP 385

  Fly   441 NEIEQIIAELPEVEHVCVVGVRDA---RYGDAAGALIIKKEGAEIADQKVI-DHVAQRVVVDYKQ 501
            ||:|.:|.:        |.||.|.   :..:...|.||....::....|:: |::|     .|||
Worm   386 NEVEDVIRK--------VEGVLDCAVYQNQEKLTAKIIGNPDSKADIFKIVKDNLA-----SYKQ 437

  Fly   502 LNAGVIFVDKFPKNANGKVMRSL 524
            |: .||||::.|:|.:||::|.:
Worm   438 LD-DVIFVEELPRNPSGKLVRHM 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	130/532 (24%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	127/499 (25%)
C32E8.6	NP_740831.1	AFD_class_I	57..455	CDD:388389	122/477 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910