Protein Alignment CG4563 and ACSM1

DIOPT Version :10

• Sequence 1: NP_611913.1
• Gene: CG4563 / 37901
• FlyBaseID: FBgn0035006
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_443188.2
• Gene: ACSM1 / 116285
• HGNCID: 18049
• Length: 577
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 121/514 - (23%)
• Similarity: 196/514 - (38%)
• Gaps: 95/514 - (18%)

  Fly    70 RIA-LFFKSEGLTQEDRVGIIANSSTFVIP----VATACFFQATPFHAVNYSREPAIVQGLYSVT 129
            |:| :|.::.||.|.|.:.::...    :|    ||..|......|.......:...:.....::
Human    97 RVANVFTQTCGLQQGDHLALMLPR----VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLS 157

  Fly   130 KPK-IMFID--GPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGD 191
            |.| |:.||  ..:.|.|.........||:......||......|||....|...|.:...   |
Human   158 KAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTL---D 219

  Fly   192 QIAVVLCSSGTAGLPKAVALSH--------------RHIASTN-SLCISTDVLYTSATI-----D 236
            .: |:..:|||.|.||....||              |.:.::: |.|:| |..:..|||     .
Human   220 PM-VIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLS-DSGWIVATIWTLVEP 282

  Fly   237 WMTGFSITVMNLTCGFTRIISRRTFSAETALYLVSKYKVTCLAMAPW---QAYELFTSPLATSEQ 298
            |..|.::.:.:|....|::|      .:|.|    ||.:...    |   ..|.:......||.:
Human   283 WTAGCTVFIHHLPQFDTKVI------IQTLL----KYPINHF----WGVSSIYRMILQQDFTSIR 333

  Fly   299 LESLKIAFVIGGWISLALLRRAQELLPKTYVMF--SYGTTETGVVTINIDHSLECS--------- 352
            ..:|:..:. ||  .:.|.:..:|...:|.::.  :||.:|||::         |:
Human   334 FPALEHCYT-GG--EVVLPKDQEEWKRRTGLLLYENYGQSETGLI---------CATYWGMKIKP 386

  Fly   353 --VGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIG--------LKWEGYLSNPEDTATTLQDGWI 407
              :|:..|...:::..:.|..|..|..|.:.|.|.        :.:||   :||.||......:.
Human   387 GFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEG---DPEKTAKVECGDFY 448

  Fly   408 NLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRDARYGDAAGA 472
            |.||.|..||:..:..:.|..|::........|.|:|..:.|.|.|....|||..|...|:...|
Human   449 NTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKA 513

  Fly   473 LIIKKEG--AEIADQ--KVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGKVMRSLARE 527
            .|:....  :...||  |.:....:.|...||.... |.||.:.||...||:.|...|:
Human   514 FIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK-VEFVSELPKTITGKIERKELRK 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:341237	119/506 (24%)
ACSM1	NP_443188.2	MACS_euk	45..574	CDD:341251	121/514 (24%)