DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4563 and dip2a

DIOPT Version :9

Sequence 1:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_009302675.1	Gene:	dip2a / 100332244	ZFINID:	ZDB-GENE-091204-2	Length:	1589	Species:	Danio rerio

Alignment Length:	664	Identity:	138/664 - (20%)
Similarity:	230/664 - (34%)	Gaps:	188/664 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PRPTVYDHNTSVG---QIVFNSL------RCWPTNVIQITDDD---------------------- 55
            |:|......|.||   .||.|.:      :....:|.|:.|.|
Zfish   958 PKPRQKQPGTEVGPASMIVGNLVAGKRIAQACGRDVTQLEDHDQFLYLQDVLQWRAQATPDHPLF 1022

  Fly    56 ------GTVLTNADMLAY---ATRIALFFKSEG-LTQEDRVGIIANSSTFVIPVATACFFQATPF 110
                  |||:..|..:..   |.|:||.....| |...|.|.::......:|.....|.:..
Zfish  1023 LLLNSKGTVVNTASCVQLHKRAERVALALMERGRLNAGDHVALLYPPGIDLIATFYGCLYAG--- 1084

  Fly   111 HAVNYSREPAIVQGLYSVTKPKIMFIDGPDYDRIKEITKE----WSPKLITLTGKVEGVTSIEDL 171
             .|..:..|...|.| :.|.|.:..        |.|::|.    .:..::.|....|...:::
Zfish  1085 -CVPVTVRPPHPQNL-TTTLPTVKM--------IVEVSKSVCILTTQAIMKLLKSKEAAAAVD-- 1137

  Fly   172 VKPHP------------AEKIYVPASLATGGDQIAVVLCSSGTAGLPKAVALSHRHIASTNSLCI 224
            :|..|            ..:||.|.|    .:.:|.:..|..|.|:...|.:||   |:|::||.
Zfish  1138 IKAWPLILDTDDLPRKRLPQIYKPPS----PEMLAYLDFSVSTTGILAGVKMSH---AATSALCR 1195

  Fly   225 STDV---LYTSATI----DWMTGFSITVMNLTCGFTR----IISRRTFSAETALYL--VSKYKVT 276
            |..:   ||.|..|    |...|....:..|...::.    ::.........:|:|  ||:|||.
Zfish  1196 SIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSILVPPLELETNASLWLSAVSQYKVR 1260

  Fly   277 CLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQ---ELLPKTYVMFSY----- 333
             :....:...|:.|..|.:  |.|:|::..|     :|:.:|...   |..|:..:..|:
Zfish  1261 -VTFCSYSVMEMCTKGLGS--QTEALRLRNV-----NLSCVRTCMVVAEERPRITLTQSFSKIFK 1317

  Fly   334 ------------------------GTTETGVVTINID-----------------HSLE-CSVGRL 356
                                    ||......|:.:|                 |||. ...|::
Zfish  1318 DLGLSTRAVSTTFGCRVNVAVCLQGTAGPDPTTVYLDMRALRHDRVRLVERGSPHSLPLMESGKI 1382

  Fly   357 APGMRIKIQG-EDGQQLGVNQTGEVLIDIGLKWEGYLS-------NPEDTATTLQDG-----WIN 408
            .||:::.|.. |....||.:..|||.:.......||.:       :.:...|.|..|     |..
Zfish  1383 LPGVKVIIANTETKGPLGDSHLGEVWVSSPHNATGYYTVYGEEALHADHFNTRLSFGDTQTVWAR 1447

  Fly   409 LGDLGYF----------DEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHVCVVGVRD 463
            .|.||:.          :..:.||:|....:.|:.:...|.|.:||..:....:....|.|....
Zfish  1448 TGYLGFLRRTELTDASGERHDALYVVGALDETLELRGMRYHPIDIETSVIRSHKSIAECAVFTWT 1512

  Fly   464 ARYGDAAGALIIKKEGAEIADQKVIDHVA--QRVVVDYKQLNAGVIFV---DKFPKNANGKVMRS 523
            ...     .::::.||:|   |:.:|.||  ..||::...|..||:.|   ...|.|:.|:..|.
Zfish  1513 NLL-----VVVVELEGSE---QEALDLVALVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRM 1569

  Fly   524 LAREVF--EKTKPI 535
            ..|:.|  ::..||
Zfish  1570 HLRDGFLADQLDPI 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	136/658 (21%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	124/610 (20%)
dip2a	XP_009302675.1	DMAP_binding	19..132	CDD:283995
		CaiC	349..927	CDD:223395
		AFD_class_I	375..939	CDD:302604
		AMP-binding	1009..1483	CDD:278902	99/503 (20%)
		AFD_class_I	1026..1578	CDD:302604	124/589 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900