Protein Alignment KCNS3 and Shal

DIOPT Version :10

• Sequence 1: NP_002243.3
• Gene: KCNS3 / 3790
• HGNCID: 6302
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Alignment Length: 489
• Identity: 160/489 - (32%)
• Similarity: 251/489 - (51%)
• Gaps: 76/489 - (15%)

Human    13 DEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFR 77
            |:|.:.:||.|.:....::||.::|.|.||.     :|....     |....|||:|||:|.:||
  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLGS-----NEREFF-----YDEDCKEYFFDRDPDIFR 93

Human    78 YVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVST 142
            ::||:|.|||||..:..|:.|:.:|:.::||....|..||...|::||.||.|:..|.|..: :.
  Fly    94 HILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSE-NG 157

Human   143 DSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENP--------AYCLSAKLIAISSLSVVLASI 199
            |.:.::.:               .:|:|:|...|||        .|.::...||:|    |:|::
  Fly   158 DQNLQQLT---------------NMRQKMWRAFENPHTSTSALVFYYVTGFFIAVS----VMANV 203

Human   200 V--AMCVHSMSEFQN-EDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFV 261
            |  ..|.|....... ..||....|...::.||:..||.|..:||.|||.:.||.::.::|||.|
  Fly   204 VETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVV 268

Human   262 SIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGL 326
            :|:|:|..|.:...::.|      |..| .||:.|:|||.|.:|||.|||.||.||:....|:|.
  Fly   269 AIMPYYIGLGITDNDDVS------GAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 326

Human   327 LLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCI 391
            |:..|::.|.||:.:::..||:.:.::.||||..:|:..::|||:||||..|.|:|||::...|.
  Fly   327 LVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391

Human   392 ICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLS 456
            :.|:||:|||:.:|.:.||:.|.:.:..|    ...|..|             |:.....|...|
  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQRAD----KRKAQRK-------------ARLARIRIAKAS 439

Human   457 SVGIVVSDPDSTDA------SSIE--DN---EDI 479
            |....||...:.:|      |.||  ||   |||
  Fly   440 SGAAFVSKKKAAEARWAAQESGIELDDNYRDEDI 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS3	NP_002243.3	BTB_POZ_KCNS3	15..122	CDD:349735	37/106 (35%)
		Ion_trans	184..417	CDD:459842	88/235 (37%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		3/4 (75%)
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/114 (36%)
		Ion_trans	188..415	CDD:459842	89/237 (38%)
		DUF3399	471..535	CDD:463381	3/3 (100%)