DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15873 and PRSS55

DIOPT Version :9

Sequence 1:	NP_611910.2	Gene:	CG15873 / 37898	FlyBaseID:	FBgn0035003	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	313	Identity:	75/313 - (23%)
Similarity:	122/313 - (38%)	Gaps:	64/313 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQILTVFLGLIL--------STSLSDADLGVIGDISDETFEMLISGGYKPK--------SNRLSR 49
            |.:.:|.|.|.|        .|.|.:|.:.::|         ...|.::|:        |....|
Human     1 MLLFSVLLLLSLVTGTQLGPRTPLPEAGVAILG---------RARGAHRPQPPHPPSPVSECGDR 56

  Fly    50 HVVSIRTKNYVRHRG------------------DNHFCSGVLVSSRAVLTAAHCLTDRYKASMNP 96
            .:...||: |.|..|                  ...||.|.:::...:|||||||   |...:.|
Human    57 SIFEGRTR-YSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAHCL---YSEELFP 117

  Fly    97 RGIRVVFGHITRLAVYDESDFRSVDRLVVHPEYERYK-KNDLAILRLSERVQSSNHDVLPLLMRK 160
            ..:.||.|  |........:.:.|..:::|.:::|.. .||:|:|.|:..::..:..|...|..:
Human   118 EELSVVLG--TNDLTSPSMEIKEVASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQ 180

  Fly   161 TANVTYGDTCITLGWGQ--IYQHGPYSNELVYLDVILRPPSLCQKHYDTFTADHNVCTEPVGESM 223
            ....|:.: |...||||  .........:|:...:::.....|.|.:...| .:.:|.....||.
Human   181 PGPATWRE-CWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPKLT-KNMLCAGYKNESY 243

  Fly   224 N-CAGDMGGPLLC------KGALFGLIGGHMGCAGGKAMK--FLSFLYYKDWI 267
            : |.||.||||:|      |....|:|.....| |.|...  :.|.:.|..||
Human   244 DACKGDSGGPLVCTPEPGEKWYQVGIISWGKSC-GEKNTPGIYTSLVNYNLWI 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15873	NP_611910.2	Tryp_SPc	36..250	CDD:214473	59/249 (24%)
CG15873	NP_611910.2	Tryp_SPc	59..250	CDD:238113	53/218 (24%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	57/235 (24%)
		Tryp_SPc	68..298	CDD:238113	58/236 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910