DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42383 and UBXN2A

DIOPT Version :9

Sequence 1:	NP_523847.2	Gene:	CG42383 / 37897	FlyBaseID:	FBgn0259729	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_859064.2	Gene:	UBXN2A / 165324	HGNCID:	27265	Length:	259	Species:	Homo sapiens

Alignment Length:	203	Identity:	64/203 - (31%)
Similarity:	106/203 - (52%)	Gaps:	23/203 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 PADDEHTI-VVLHLWSEGFSLDDGSLRLYALPENERFLRAILRGDFPEEMLRV---PRVQLSVQD 211
            ||:.:..: |.:.||..||:::| ..|.|:...:::||.:|.:|:.|.|:..:   ..|.:.|:|
Human    54 PAEQKKQVDVNIKLWKNGFTVND-DFRSYSDGASQQFLNSIKKGELPSELQGIFDKEEVDVKVED 117

  Fly   212 HTNESYRHLSRK----QFMGPGRPLNSPSPQILVVGPMPVEAQ------GLQLNERADTTTVQLR 266
            ..||..  ||.|    .|.|.|..|.|.:|:| |.....:|.:      .:.||.....|.:|:.
Human   118 KKNEIC--LSTKPVFQPFSGQGHRLGSATPKI-VSKAKNIEVENKNNLSAVPLNNLEPITNIQIW 179

  Fly   267 MADGSRVAGRFNLTHNVGDLYQYARLARPEFSDRS--FVLMTAFPRQELVESDTRTLVQANLCNV 329
            :|:|.|:..:||:||.|..:..:  :.:.:.|.||  |.|.||.|...|:: :|.||.:|:|.|.
Human   180 LANGKRIVQKFNITHRVSHIKDF--IEKYQGSQRSPPFSLATALPVLRLLD-ETLTLEEADLQNA 241

  Fly   330 VVIQHLNE 337
            |:||.|.:
Human   242 VIIQRLQK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42383	NP_523847.2	UBA_TAP-C_like	10..39	CDD:270459
		SEP	155..242	CDD:197786	29/94 (31%)
		p47_UBX	257..336	CDD:176365	28/80 (35%)
UBXN2A	NP_859064.2	SEP	65..138	CDD:311829	23/75 (31%)
UBXN2A	NP_859064.2	p47_UBX	170..248	CDD:176365	28/80 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175850at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870