DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42383 and UBXN2B

DIOPT Version :9

Sequence 1:	NP_523847.2	Gene:	CG42383 / 37897	FlyBaseID:	FBgn0259729	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_001071087.1	Gene:	UBXN2B / 137886	HGNCID:	27035	Length:	331	Species:	Homo sapiens

Alignment Length:	342	Identity:	104/342 - (30%)
Similarity:	163/342 - (47%)	Gaps:	74/342 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PEKSSEHSQAN----ESNRDLHSLLSEISRRKEGDHDGYQACASDS------------------- 91
            ||...:..:::    .|.|||...|:|:       ::....|.|..
Human     7 PEPGEQERRSSGPRPPSARDLQLALAEL-------YEDEVKCKSSKSNRPKATVFKSPRTPPQRF 64

  Fly    92 -STDHD--------TPAGKRVN-------------INSSTPAITNNDSDRSLRVWGHGNRLGSAH 134
             |::|:        ...||.||             :|.:|.|   :..|:|....|.|.||||:.
Human    65 YSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRA---SGDDKSKSFTGGGYRLGSSF 126

  Fly   135 PINPPPRSATEDSDTEPADDEHTIVVLHLWSEGFSLDDGSLRLYALPENERFLRAILRGDFPEEM 199
                ..||.....:.:..|.:   ::|.|||.|||||||.||.|..|.|.:||.::.||:.|.|:
Human   127 ----CKRSEYIYGENQLQDVQ---ILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEIPLEL 184

  Fly   200 LRV---PRVQLSVQDHTNESY--RHLSRKQFMGPGRPLNSPSPQILVVGPMPVEAQGLQLN---- 255
            .|:   .:|.|.::||.::.|  ..|..|.|.|.|:.|.|.:|:|:.....|.|.....||
Human   185 QRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAVVL 249

  Fly   256 --ERADTTTVQLRMADGSRVAGRFNLTHNVGDLYQYARLARPEFSDRSFVLMTAFPRQELVESDT 318
              :...||.:|:|:|||||:..|||.||.:.|:..:...:||||:...|:|:|:||.:||.: ::
Human   250 IDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFILVTSFPNKELTD-ES 313

  Fly   319 RTLVQANLCNVVVIQHL 335
            .||::|::.|.|::|.|
Human   314 LTLLEADILNTVLLQQL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42383	NP_523847.2	UBA_TAP-C_like	10..39	CDD:270459
		SEP	155..242	CDD:197786	37/91 (41%)
		p47_UBX	257..336	CDD:176365	33/79 (42%)
UBXN2B	NP_001071087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..65		2/24 (8%)
		SEP	140..232	CDD:197786	38/94 (40%)
		p47_UBX	253..331	CDD:176365	33/79 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175850at2759
OrthoFinder	1	1.000	-	-		FOG0001623
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23333
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5790
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.930