DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and SLC6A5

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_004202.4	Gene:	SLC6A5 / 9152	HGNCID:	11051	Length:	797	Species:	Homo sapiens

Alignment Length:	677	Identity:	267/677 - (39%)
Similarity:	392/677 - (57%)	Gaps:	80/677 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ATTGRSNPAPWSDDKESPNN------------EDDSNEDDGDHT-----------------TPAK 49
            |...:::|.|.|   ..|.|            |.|:|...|..|                 |...
Human   100 AQGAQASPPPGS---SGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVL 161

  Fly    50 VTDPLAPKLANNERILVVSVTE-------RTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQN 107
            .||.:...|..:  :..|:..|       :.|..|..|.:|:|:::|:||.|||||||||:.:||
Human   162 ATDGITSVLPGS--VATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQN 224

  Fly   108 GGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYN 172
            ||||||:||.:.|...|||:|::|::||||...|.:|:||.| |||:|.|.|:.:|.:.:.:|||
Human   225 GGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYN 288

  Fly   173 TIIGWAVYYLFASFTSKLPWTSCDNPWNTENCM-------------------------------Q 206
            .||.:.::||||||.|.|||.||:|||||..|.                               .
Human   289 VIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPN 353

  Fly   207 VTSENFTELA----TSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVR 267
            ||..|||..|    .|.::|:|:..||:.  ..|:::.|.::..||||:|..:|:||.||.||::
Human   354 VTMVNFTSQANKTFVSGSEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIK 416

  Fly   268 SAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPG 332
            ::||||:.||..|||||:|||:|||:||||..||.|::||:|.||.::.||.|||:||||||...
Human   417 TSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAA 481

  Fly   333 FGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLV 397
            :|.|:.|||||||:||||||.||.:..|..||..||||||||:|:||..:|.:|:.|..:|||:.
Human   482 WGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIA 546

  Fly   398 FIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLA 462
            |:|||||:..:..|.||:|||||||:|||||:.|..:|.::|::.||:|:.:...:.:|.|....
Human   547 FVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCI 611

  Fly   463 FIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLF 527
            ..|:...|.:|.||:.:...::.|....|::.:...|..|:.:.||:.||..|:|.|:|.:|.:|
Human   612 CFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIF 676

  Fly   528 WRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFAS 592
            |::||.:::|..|..|..||...::.|....|.||:||..:||.:...||:.||:..:.|...|
Human   677 WKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLA- 740

  Fly   593 KGGCRQRLQESFQPEDNCGSVVPGQQG 619
            .|...:||:....|:.:.|..:...:|
Human   741 PGRFIERLKLVCSPQPDWGPFLAQHRG 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	247/567 (44%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		6/20 (30%)
SLC6A5	NP_004202.4	SLC6sbd_GlyT2	191..787	CDD:271389	250/581 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820