DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and Slc6a11

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_077348.1	Gene:	Slc6a11 / 79213	RGDID:	628737	Length:	627	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	251/586 - (42%)
Similarity:	363/586 - (61%)	Gaps:	33/586 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            |..|..|.||:|:|.|..:.|||||||||:||:|||||||:||.:|.|..|:|:|::|.|||||.
  Rat    45 RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFT 109

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            ..|.::.|:|:||..:|:|||..:|:.::.:||..|:.||::||...||::|||.:|.:.||||.
  Rat   110 SEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEK 174

  Fly   204 CMQVTSENFT-------ELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFS 261
            |::....||:       :.||||..||:||:||..  .:|::.:|.::..||||:...:.:.||.
  Rat   175 CVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAI--SDGIEHIGNLRWELALCLLAAWTICYFC 237

  Fly   262 LWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIF 326
            :|||.:|.||||:|||..||::|:|||:|||:||||.||||:||.|:..:|.:.:||:||.:|||
  Rat   238 IWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIF 302

  Fly   327 FSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGL 391
            ||.....|.|.||.|||.:|||||||.::...:|..|||:|||.||||||:|||.|...|.:|..
  Rat   303 FSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAE 367

  Fly   392 EGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVI--GRRRE 454
            .||||.||.||:|:..|..|..|:.:||:|||.|||||.|..:|:::||:.|.||:|.  |.|||
  Rat   368 SGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRE 432

  Fly   455 LFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQ 518
            |.:|.|....:...|..:|.||:.:....:.| ..|:.:|||...|...:.|.||.:||..::|.
  Rat   433 LLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIED 497

  Fly   519 MLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM-LGEEYYYPDWSYQVGWAVTCSSVLCIPM 582
            |:|.:|....:.||..::|.....||||.::.||.: ....|.||.|.|.:||.:..||:||||:
  Rat   498 MIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPL 562

  Fly   583 YIIYKFFFASKGGCRQRLQESFQPE------------------DNCGSVVPGQQGTSVXHDHAQV 629
            :|..| .:.::|...::||:...|.                  ::|.:.|.| .||.. ....:.
  Rat   563 WIFIK-LWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKG-DGTISAITEKET 625

  Fly   630 H 630
            |
  Rat   626 H 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	244/543 (45%)
Slc6a11	NP_077348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_077348.1	SLC6sbd_GAT3	44..585	CDD:212077	244/542 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830