Protein Alignment SerT and Slc6a21

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_006541333.1
• Gene: Slc6a21 / 76713
• MGIID: 1923963
• Length: 749
• Species: Mus musculus
• Alignment Length: 652
• Identity: 170/652 - (26%)
• Similarity: 296/652 - (45%)
• Gaps: 127/652 - (19%)

  Fly    35 DDSNED---------DGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGF 90
            |.|.||         :..||...|..:|.:  ::...|...|.||:.......:|.|.:|.::.|
Mouse     2 DQSFEDFLELKNKPVEEVHTASKKSDNPTS--VSRGFRTREVRVTKIPNHFQAKKTENILILVAF 64

  Fly    91 AVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKG 155
            ::.||:.|||||:|:|||||:||:.|.:.|:..|:||.|||:.:||:.|...:..||.:.|.|.|
Mouse    65 SIGLGSTWRFPYLCHQNGGGSFLLMYFILLLLLGIPLMYMEMVIGQWLRMDNIQAWKYLVPWLSG 129

  Fly   156 VGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPA 220
            |||:..|..:.:.:|.:.::.|:::||..||...|||.:|.   ..||...|...  |.|.:.|.
Mouse   130 VGYSNILACVLVVLYNSALVSWSLFYLGQSFDYPLPWQNCP---LVENLSMVAGN--TCLWSEPH 189

  Fly   221 KEFFERKVLE--SYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVV 283
            :.|:...:|:  :....|::.:   ...:.||:|..::.:|.::...::.:..::..:.|...|:
Mouse   190 QYFWYHTLLQASNQMEEGIEVL---VLNVTLCLFATWIFLYVTMVTRIKISVLMMIFSILFSNVL 251

  Fly   284 LIILLVRGVSLPGADEGIKYYL-TPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNN 347
            |:...:|.:.|.|:.....:.| |.|...|.:...|..|...:.:|||.|.||::..|:|.....
Mouse   252 LLCFFIRTLFLNGSVRASLWRLVTIELSILSSLDAWRQAGGHVLYSLGLGMGTIITFSTYQPRGE 316

  Fly   348 NCYRDALITSSINCLTSFLAGFVIFSVLG------------------------------------ 376
            |..:.|...:.:|..||.|:.||||.|:|
Mouse   317 NYIKWASFVAMVNLATSLLSSFVIFLVMGFWTTTSGTMCIKRSVSNLINLIANGVLPKAAWPPGD 381

  Fly   377 --------YMAY----------------------VQKTSIDKVGLEGPGLVFIVYPEAIATMSGS 411
                    |:|:                      :||..|    :|||||.::.:.:||:...||
Mouse   382 IIHKPPLEYLAWINQLPNNLKSQVIHQTLPCSILIQKEKI----MEGPGLSYVAFSQAISLFPGS 442

  Fly   412 VFWSIIFFLMLITLGLDSTFGGLEAMITAL------CDEYPRVIGRRRELFVLL--LLAFIFLCA 468
            .||:||||:.|..:||.:....||.::..|      ..::|.::    ::.|.|  .|..:...:
Mouse   443 SFWAIIFFMSLAIMGLGTMLTLLEGIVLPLQKSISTFAKHPNLV----QVLVCLGGFLGSLVFSS 503

  Fly   469 LPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFW---RI 530
            .|    |..|:..|.::..| :.::.:|.::...:.|.||:.||.::|...|||   |.|   ..
Mouse   504 RP----GSYVVFLFDDLLVP-MVLIIIVVIQNLSLAWLYGIKRFRAEVFGQLGS---LVWSPFTF 560

  Fly   531 CWTYIS-P--VFLLTIFIFSI--------MGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYI 584
            .|:|:: |  :.||||:..::        :.:.:.:..|...|.....:|| ||..|||.:...:
Mouse   561 LWSYVTLPTLLVLLTIYFLNLYYSGSPYYVSWNDSMSHEVKQPYKKIPLGW-VTFLSVLALLPIL 624

  Fly   585 IY 586
            :|
Mouse   625 VY 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	158/604 (26%)
Slc6a21	XP_006541333.1	SLC5-6-like_sbd	48..622	CDD:382020	157/598 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920