Protein Alignment SerT and slc6a4a

DIOPT Version :10

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_001035061.1
• Gene: slc6a4a / 664719
• ZFINID: ZDB-GENE-060314-1
• Length: 646
• Species: Danio rerio
• Alignment Length: 627
• Identity: 323/627 - (51%)
• Similarity: 423/627 - (67%)
• Gaps: 31/627 - (4%)

  Fly    17 GRSNPAPWSDDK------ESPNNEDDSNEDDGDHTTPAKVTDPLAPK-----------LANNERI 64
            |.....|.|.:.      ..|..:..|....|..:...:.|.|.:||           .....|.
Zfish    15 GEQQKVPESQENGRLVVDSVPEKDQKSGSGPGQVSNGYRSTSPQSPKEGAGTGTDRVNTPGTFRT 79

  Fly    65 LVVSVT--ERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPL 127
            |||..|  :..||||.:|.:|||:|||:|||||||||||||||||||||||:||.|..:|||:||
Zfish    80 LVVQQTSLDPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPL 144

  Fly   128 FYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPW 192
            ||||||||||||.||:||||.:||..||:|:|||:|.:|:..|||||:.||:|||.:||.:.|||
Zfish   145 FYMELALGQFHRSGCISIWKHVCPIFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPW 209

  Fly   193 TSCDNPWNTENCMQVTSE----NFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFG 253
            |:|:|.|||.||....|.    ::|..:.|||:||:.|:||:.:...||..:|.|...||||:..
Zfish   210 TTCNNRWNTPNCTHYLSTDLNVSWTNNSISPAEEFYVRQVLQVHLSPGLHQLGWVSWQLALCLLF 274

  Fly   254 VFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVW 318
            :|.:||||:||||:::||||||||..||:||:|||:||.:||||..|:.:||.|:|.||..:.||
Zfish   275 IFTVVYFSIWKGVKTSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWKKLLTTTVW 339

  Fly   319 IDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQK 383
            :|||:|||||||||||.|||.:|||.|:||||:|||||||:|||||||:|||||:||||||.:::
Zfish   340 LDAAAQIFFSLGPGFGVLLAFASYNPFHNNCYKDALITSSVNCLTSFLSGFVIFTVLGYMAEMRQ 404

  Fly   384 TSIDKVGLE-GPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPR 447
            ..::.|..: ||.|:||:|.||||.|..:.|::||||||:|.|||||||.|||.:|||:.||:|.
Zfish   405 QGVETVAKDAGPSLLFIIYAEAIANMPAATFFAIIFFLMIIMLGLDSTFAGLEGVITAMLDEFPH 469

  Fly   448 VIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRF 512
            ::.||||.|||.|:...:|.||.|:||||..:|.....|..|.|::.|||:|...|.||||..||
Zfish   470 LLARRREWFVLGLVCVCYLGALSTLTYGGAFVVKLFEEYATGPAVITVVFLEVIAVSWFYGTTRF 534

  Fly   513 SSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSV 577
            .:||:.|||..||||||:||..|.|.|||.|.:..:....|:...:|.||.|:..:|:.:..||.
Zfish   535 CNDVQLMLGFAPGLFWRVCWIAICPCFLLFIIVSFLAFPPEVKLFDYLYPFWTTVLGYCIGVSSF 599

  Fly   578 LCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQG 619
            :|:|.|::| ....:||..:|||.:...||      .||..|
Zfish   600 ICVPSYMVY-HLVTTKGTFQQRLLKGITPE------APGSSG 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	303/537 (56%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:444915	303/537 (56%)