Protein Alignment SerT and slc6a4a

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_001035061.1
• Gene: slc6a4a / 664719
• ZFINID: ZDB-GENE-060314-1
• Length: 646
• Species: Danio rerio
• Alignment Length: 627
• Identity: 323/627 - (51%)
• Similarity: 423/627 - (67%)
• Gaps: 31/627 - (4%)

  Fly    17 GRSNPAPWSDDK------ESPNNEDDSNEDDGDHTTPAKVTDPLAPK-----------LANNERI 64
            |.....|.|.:.      ..|..:..|....|..:...:.|.|.:||           .....|.
Zfish    15 GEQQKVPESQENGRLVVDSVPEKDQKSGSGPGQVSNGYRSTSPQSPKEGAGTGTDRVNTPGTFRT 79

  Fly    65 LVVSVT--ERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPL 127
            |||..|  :..||||.:|.:|||:|||:|||||||||||||||||||||||:||.|..:|||:||
Zfish    80 LVVQQTSLDPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPL 144

  Fly   128 FYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPW 192
            ||||||||||||.||:||||.:||..||:|:|||:|.:|:..|||||:.||:|||.:||.:.|||
Zfish   145 FYMELALGQFHRSGCISIWKHVCPIFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPW 209

  Fly   193 TSCDNPWNTENCMQVTSE----NFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFG 253
            |:|:|.|||.||....|.    ::|..:.|||:||:.|:||:.:...||..:|.|...||||:..
Zfish   210 TTCNNRWNTPNCTHYLSTDLNVSWTNNSISPAEEFYVRQVLQVHLSPGLHQLGWVSWQLALCLLF 274

  Fly   254 VFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVW 318
            :|.:||||:||||:::||||||||..||:||:|||:||.:||||..|:.:||.|:|.||..:.||
Zfish   275 IFTVVYFSIWKGVKTSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWKKLLTTTVW 339

  Fly   319 IDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQK 383
            :|||:|||||||||||.|||.:|||.|:||||:|||||||:|||||||:|||||:||||||.:::
Zfish   340 LDAAAQIFFSLGPGFGVLLAFASYNPFHNNCYKDALITSSVNCLTSFLSGFVIFTVLGYMAEMRQ 404

  Fly   384 TSIDKVGLE-GPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPR 447
            ..::.|..: ||.|:||:|.||||.|..:.|::||||||:|.|||||||.|||.:|||:.||:|.
Zfish   405 QGVETVAKDAGPSLLFIIYAEAIANMPAATFFAIIFFLMIIMLGLDSTFAGLEGVITAMLDEFPH 469

  Fly   448 VIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRF 512
            ::.||||.|||.|:...:|.||.|:||||..:|.....|..|.|::.|||:|...|.||||..||
Zfish   470 LLARRREWFVLGLVCVCYLGALSTLTYGGAFVVKLFEEYATGPAVITVVFLEVIAVSWFYGTTRF 534

  Fly   513 SSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSV 577
            .:||:.|||..||||||:||..|.|.|||.|.:..:....|:...:|.||.|:..:|:.:..||.
Zfish   535 CNDVQLMLGFAPGLFWRVCWIAICPCFLLFIIVSFLAFPPEVKLFDYLYPFWTTVLGYCIGVSSF 599

  Fly   578 LCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQG 619
            :|:|.|::| ....:||..:|||.:...||      .||..|
Zfish   600 ICVPSYMVY-HLVTTKGTFQQRLLKGITPE------APGSSG 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	303/537 (56%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:294310	303/537 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	671	1.000	Domainoid score	I140
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	682	1.000	Inparanoid score	I681
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm26087
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4270
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910