Protein Alignment SerT and SLC6A13

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 248/599 - (41%)
• Similarity: 364/599 - (60%)
• Gaps: 35/599 - (5%)

  Fly    45 TTPAKVTDPLAPKLANNERILVVSVTERTRET--WGQKAEFLLAVIGFAVDLGNVWRFPYICYQN 107
            ||....|.|:.|.:...|.       :.|.|.  |..|.||:|:|.|..:.|||||||||:||:|
Human     8 TTSNGETKPVYPVMEKKEE-------DGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKN 65

  Fly   108 GGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYN 172
            |||||.:||.:||...|:|:|.:|.||||:...|.::.|::|||..:|:|||..:|.|.:.:||.
Human    66 GGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYI 130

  Fly   173 TIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQV---------TSENFTELATSPAKEFFERKV 228
            .::.||::|||:|||..|||..|.:.||||:||:.         ||||    ||||..||:||:|
Human   131 IVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSEN----ATSPVIEFWERRV 191

  Fly   229 LESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVS 293
            |:.  .:|:..:|.::..||||:...:|:.||.:||||:|.||||:.||..||::|::||:|||:
Human   192 LKI--SDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVT 254

  Fly   294 LPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSS 358
            ||||.:||::||.|...:|.:.:||:||.:|||||.....|.|.||.||||::||||||.:....
Human   255 LPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCF 319

  Fly   359 INCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLI 423
            :|..|||:|||.|||:||:|:..|...|.:|...||||.||.||.|:..:..|..|:..||.|::
Human   320 LNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVV 384

  Fly   424 TLGLDSTFGGLEAMITALCDEYPRVIGR--RRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY 486
            .|||||.|..:|:::|||.|.||.|..:  |||:.:|.:....||..|..:|.||:.:....:.|
Human   385 LLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYY 449

  Fly   487 -GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMG 550
             ..|:.:|||...|:..|.|.||..||..::|.|:|.:|....:.||.:::|......|:||::.
Human   450 AASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK 514

  Fly   551 YKEM-LGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDN----- 609
            |..: ..::|.||.|...:||.:..||::|||.:.:|: ....||..|:|:::...|.::
Human   515 YTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYR-LGTLKGPFRERIRQLMCPAEDLPQRN 578

  Fly   610 -CGSVVPGQQGTSV 622
             .|...|....||:
Human   579 PAGPSAPATPRTSL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	236/547 (43%)
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/13 (38%)
		SLC6sbd_GAT2	32..575	CDD:271396	236/549 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830