DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and SLC6A12

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001116319.1	Gene:	SLC6A12 / 6539	HGNCID:	11045	Length:	614	Species:	Homo sapiens

Alignment Length:	554	Identity:	239/554 - (43%)
Similarity:	357/554 - (64%)	Gaps:	25/554 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQ 136
            :.|..|..|.||:|:|.|..:.|||||||||:||:||||||.:||.:|....|:|:|::|:||||
Human    34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQ 98

  Fly   137 FHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNT 201
            :...|.::.|::|||..:|:|.|..:|:.|:.:||..|:.||::|||:||||:||||:|:|.|||
Human    99 YTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNT 163

  Fly   202 ENCMQVTS----------ENFTELATSPAKEFFERKVLESYKG--NGLDFMGPVKPTLALCVFGV 254
            |:|....:          |||    |||..||:||:||    |  :|:..:|.::..||||:...
Human   164 EHCTDFLNHSGAGTVTPFENF----TSPVMEFWERRVL----GITSGIHDLGSLRWELALCLLLA 220

  Fly   255 FVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWI 319
            :|:.||.:||||:|.||||:.||..||::|:|||:|||:||||.:||.|||.|:..:||:.:||:
Human   221 WVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWM 285

  Fly   320 DAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKT 384
            ||.:|||||.....|.|.||.||||::||||:|.:....:|..|||:||||:||:||:|:..|..
Human   286 DAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGV 350

  Fly   385 SIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVI 449
            .|.:|...||||.||.:|:|:..|..|..||.:||:|||.|||||.|..:|.::||..|.:||.:
Human   351 PISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

  Fly   450 GR--RRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDR 511
            .:  ||||.:|.:....:|..|..:|.||:.:....:.| ..|:.:||:...|...:.|.||.||
Human   416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 480

  Fly   512 FSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM-LGEEYYYPDWSYQVGWAVTCS 575
            |..::|.|:|.:|....:|.|.:::|...|..|:||:..|..: ....|.||.|.|.:||.:..|
Human   481 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALS 545

  Fly   576 SVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDN 609
            |::|:|::::.. ...::|..|:||::...|:.:
Human   546 SMVCVPLFVVIT-LLKTRGPFRKRLRQLITPDSS 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	238/548 (43%)
SLC6A12	NP_001116319.1	SLC6sbd_BGT1	35..575	CDD:212080	238/548 (43%)
SLC6A12	NP_001116319.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..614		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830