Protein Alignment SerT and SLC6A11

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_055044.1
• Gene: SLC6A11 / 6538
• HGNCID: 11044
• Length: 632
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 256/626 - (40%)
• Similarity: 380/626 - (60%)
• Gaps: 39/626 - (6%)

  Fly    10 AGAAATTGRSNPAPWSDDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTR 74
            |..|...|....|..:.:.|:|.....|.     ...||:     .|::..::.:       ..|
Human     3 AEKALPLGNGKAAEEARESEAPGGGCSSG-----GAAPAR-----HPRVKRDKAV-------HER 50

  Fly    75 ETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHR 139
            ..|..|.||:|:|.|..:.|||||||||:||:|||||||:||.:|.|..|:|:|::|.|||||..
Human    51 GHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTS 115

  Fly   140 CGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENC 204
            .|.::.|:::||..:|:|||..:|:.::.:||..|:.||::||...||::|||.:|.:.||||||
Human   116 EGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC 180

  Fly   205 MQ---VTSENFTEL----ATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSL 262
            ::   :...|::.:    ||||..||:|.:||..  .:|::.:|.::..||||:...:.:.||.:
Human   181 VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAI--SDGIEHIGNLRWELALCLLAAWTICYFCI 243

  Fly   263 WKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFF 327
            |||.:|.||||:|||..||::|:|||:|||:||||.||||:||.|:..:|.:.:||:||.:||||
Human   244 WKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFF 308

  Fly   328 SLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLE 392
            |.....|.|.||.|||.:|||||||.::...:|..|||:|||.||||||:|||.|...|.:|...
Human   309 SYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES 373

  Fly   393 GPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVI--GRRREL 455
            ||||.||.||:|:..|..|..|:.:||:|||.|||||.|..:|:::||:.|.||:|.  |.||||
Human   374 GPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRREL 438

  Fly   456 FVLLLLAFIFLCALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQM 519
            .:|.|....:...|..:|.||:.:....:.| ..|:.:|||...|...:.|.||.:||..::|.|
Human   439 LILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDM 503

  Fly   520 LGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM-LGEEYYYPDWSYQVGWAVTCSSVLCIPMY 583
            :|.:|....:.||..::|.....||||.::.||.: ....|.||.|.|.:||.:..||:||||::
Human   504 IGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLW 568

  Fly   584 I---IYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQGTS 621
            |   ::|    ::|...::||:...|..:.  .:.|:.|.|
Human   569 ICITVWK----TEGTLPEKLQKLTTPSTDL--KMRGKLGVS 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	242/546 (44%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		10/47 (21%)
		SLC6sbd_GAT3	49..590	CDD:212077	242/546 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830