Protein Alignment SerT and SLC6A8

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_005620.1
• Gene: SLC6A8 / 6535
• HGNCID: 11055
• Length: 635
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 261/598 - (43%)
• Similarity: 361/598 - (60%)
• Gaps: 33/598 - (5%)

  Fly    26 DDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGF 90
            |:|:.|...      .|....|||...|:.  |......|.|.    .||||.::.:|:::.:||
Human    16 DEKKGPLIA------PGPDGAPAKGDGPVG--LGTPGGRLAVP----PRETWTRQMDFIMSCVGF 68

  Fly    91 AVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKG 155
            ||.|||||||||:||:||||.||:||.|..:.||:|:|::|::||||.:.|.:::| .|||..||
Human    69 AVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVW-NICPLFKG 132

  Fly   156 VGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQV---------TSEN 211
            :|||..:|..|...||..::.|..|||..|||:.|||.:|.:.|||.:|:::         :..|
Human   133 LGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLAN 197

  Fly   212 FT--ELA--TSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKV 272
            .|  :||  .||..||:|.|||.  ...||:..|.:...:.||:...:|||||.:||||:|.||:
Human   198 LTCDQLADRRSPVIEFWENKVLR--LSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKI 260

  Fly   273 VWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLL 337
            |:.||..|||||::||||||.||||.:||.|||.|:|.||.:.:|||||.:|||||...|.|.|.
Human   261 VYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALT 325

  Fly   338 ALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYP 402
            ||.|||:||||||:||:|.:.||..|||.||||:||:||:||..|...|.||...||||.||.||
Human   326 ALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYP 390

  Fly   403 EAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRR--RELFVLLLLAFIF 465
            .|:..|..:..|:.:||.||:.|||||.|.|:|..||.|.|..|.....|  ||:.|.|..|..|
Human   391 RAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCF 455

  Fly   466 LCALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWR 529
            :..|..:|.||:.:....:.| ..|..:|:..|.|...|.|.||.|||..|:..|:|.:|..:.:
Human   456 VIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMK 520

  Fly   530 ICWTYISPVFLLTIFIFSIMGYKEML-GEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASK 593
            .||::.:|:..:.||||:::.|:.:: ...|.||.|...:|||...||:||:|:::: .....:|
Human   521 WCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLL-GCLLRAK 584

  Fly   594 GGCRQRLQESFQP 606
            |...:|.|...||
Human   585 GTMAERWQHLTQP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	250/550 (45%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		4/17 (24%)
		SLC6sbd_CT1	52..621	CDD:271397	250/550 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830