Protein Alignment SerT and SLC6A7

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_016865256.1
• Gene: SLC6A7 / 6534
• HGNCID: 11054
• Length: 754
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 244/583 - (41%)
• Similarity: 342/583 - (58%)
• Gaps: 47/583 - (8%)

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            |..|..|.:|||:.||:.|.|||||||||..|.||||||||||.|.|...|:|||::||:||||.
Human   118 RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFS 182

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            ..|.|::|| |.|..||.|.|:.||...:.:|||.||.:.::|||||.||.|||..|.|.||||.
Human   183 SLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTEL 246

  Fly   204 CMQ-----------------------------------------VTSENFTELATSP----AKEF 223
            |::                                         |.|.::.::...|    |:|.
Human   247 CLEHRVSKDGNGALPLNLTCTVSPSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEG 311

  Fly   224 FERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILL 288
            ..|.||......|:...|.::..|.||:...:|:|:..:.|||:|:||||:.||..||::|::||
Human   312 VSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLL 376

  Fly   289 VRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDA 353
            ||||:||||.:||::||||::|.|.:|||||:||.|||:|||.|||.||..:|||.|:.|.|||.
Human   377 VRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDT 441

  Fly   354 LITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIF 418
            .|.:..|.:||.||||.||||||||:......:|:|...||||.|:|||:|:..:..|.|||.:|
Human   442 FIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLF 506

  Fly   419 FLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFL 483
            |.||:||||||.|..||.::||:.||:|..:..::.:|..|:...::|..|...|.||:..:..|
Human   507 FFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLL 571

  Fly   484 NVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSI 548
            :.|.....::.||......|...||:.||..|:..|||.||||::|.||.::||..||.:.::||
Human   572 DDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSI 636

  Fly   549 MGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCG 611
            :.|:......|.:|.|:..:|..:...|.|.||..::.. ....:|...:|||::.:|..:.|
Human   637 VKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVA-VLREEGSLWERLQQASRPAMDWG 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	242/577 (42%)
SLC6A7	XP_016865256.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820